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PATJ Inhibits Histone Deacetylase 7 to Control Tight Junction Formation and Cell Polarity
Abstract: The conserved multiple PDZ-domain containing protein PATJ stabilizes the Crumbs-Pals1 complex to regulate apical-basal polarity and tight junction formation in epithelial cells. However, the molecular mechanism of PATJ's function in these processes is still unclear. In this study, we demonstrate that knockout of PATJ in epithelial cells results in tight junction defects as well as in a disturbed apical-basal polarity and impaired lumen formation in three-dimensional cyst assays. Mechanistically, we found PATJ to associate with and inhibit histone deacetylase 7 (HDAC7). Inhibition or downregulation of HDAC7 restores polarity and lumen formation. Gene expression analysis of PATJ-defi...
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Food Components to Enhance Performance
The physiological or psychological stresses that employees bring to their workplace affect not only their own performance but that of their co-workers and others. These stresses are often compounded by those of the job itself. Medical personnel, firefighters, police, and military personnel in combat settingsâ€"among othersâ€"experience highly unpredictable timing and types of stressors. This book reviews and comments on the performance-enhancing potential of specific food components. It reflects the views of military and non-military scientists from such fields as neuroscience, nutrition, physiology, various medical specialties, and performance psychology on the most up-to-date research available on physical and mental performance enhancement in stressful conditions. Although placed within the context of military tasks, the volume will have wide-reaching implications for individuals in any job setting.
Edward Fitz Randolph Branch Lines, Allied Families, and English and Norman Ancestry
Edward Fitz Randolph (1607-1675/1676) immigrated from England to Scituate, Massachusetts in 1630, and married Elizabeth Blossom in 1637. Descendants lived throughout the United States, and some continued to use the last given name of "Fitz."
Multiple Sclerosis Rehabilitation
"MS is always in the back of your mind. If there is something you want to do, you always wonder if the MS will allow you do to it." —Darlene, living with MS for 22 years Living with multiple sclerosis (MS) is challenging and multidimensional. MS pervades all aspects of life: one’s body becomes unpredictable and unreliable, one’s identity and sense of self are tested, and relationships with others often change. MS symptoms emerge and remit; limitations evolve and progress. MS rehabilitation is an active, person-centered, and goal-oriented process embedded within a respectful and collaborative partnership between the person with MS and the members of his or her rehabilitation treatment t...
German Immigrants
The second volume of German Immigrants provides information on about 35,000 German immigrants from Bremen who arrived in New York from 1855 to 1862. The names are arranged alphabetically, and family members are grouped together, usually under the head of the household. In addition, data on age, place of origin, date of arrival, and the name of the ship are supplied, plus citations to the original source material.
Language Processing and Knowledge in the Web
This book constitutes the refereed conference proceedings of the 25th International Conference on Language Processing and Knowledge in the Web, GSCL 2013, held in Darmstadt, Germany, in September 2013. The 20 revised full papers were carefully selected from numerous submissions and cover topics on language processing and knowledge in the Web on several important dimensions, such as computational linguistics, language technology, and processing of unstructured textual content in the Web.
Goethe Yearbook 25
Cutting-edge scholarly articles on diverse aspects of Goethe and the Goethezeit, featuring in this volume a special section on acoustics around 1800. The Goethe Yearbook is a publication of the Goethe Society of North America, encouraging North American Goethe scholarship by publishing original English-language contributions to the understanding of Goethe and other authors of the Goethezeit while also welcoming contributions from scholars around the world. Volume 25 features a special section on acoustics around 1800, edited by Mary Helen Dupree, which includes, among others, contributionson sound and listening in Ludwig Tieck's Der blonde Eckbert (Robert Ryder) and on the role of the tympan...
