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PATJ Inhibits Histone Deacetylase 7 to Control Tight Junction Formation and Cell Polarity
Abstract: The conserved multiple PDZ-domain containing protein PATJ stabilizes the Crumbs-Pals1 complex to regulate apical-basal polarity and tight junction formation in epithelial cells. However, the molecular mechanism of PATJ's function in these processes is still unclear. In this study, we demonstrate that knockout of PATJ in epithelial cells results in tight junction defects as well as in a disturbed apical-basal polarity and impaired lumen formation in three-dimensional cyst assays. Mechanistically, we found PATJ to associate with and inhibit histone deacetylase 7 (HDAC7). Inhibition or downregulation of HDAC7 restores polarity and lumen formation. Gene expression analysis of PATJ-defi...
Gibsons & Orrs: Pioneer Families
The descendants of Alexander & Elizabeth Votah Gibson and William Orr. Many of the descendants who settled in Fremont County, Iowa, are traced to the present, including biographies and photographs when available. Also included in the book is documentation of one branch of the William & Keziah Snead Keyser family.
Mutterherz Teil 2
Das Streben nach Gewinn, die Liebe für ein Kind, die Gier nach Erfolg, der Wunsch nach Erkenntnis, die Angst vor dem Unbekannten - jeder hat etwas, das ihn antreibt – so auch der Mörder von Christine Deubacher. Musste sie sterben, weil sie sich als Umweltaktivistin Feinde machte? Oder weil sie die Tochter eines erfolgreichen Geschäftsmannes war? Oder weil sie sich in ihren Chef verliebte? Vielleicht starb sie, weil jemand ihre Arbeitsstelle wollte oder gar, weil sie nicht in die Familie passte? Stück für Stück kommen die Ermittler der Detektei Keller in Augsburg weiter. Währenddessen hält Praktikant Tim es gegenüber seinen Kollegen und der Auftraggeberin geheim, adoptiert zu sein, um in Ruhe parallel seine dunkle Herkunft erforschen zu können.
Taking America Back
A provocative look at the relationship between the far right and the American conservative movement from the 1930s to the end of the Cold War Since 2016, many commentators have expressed shock at the so-called rise of the far right in America at the expense of “responsible” and “respectable” conservatism. But is the far right an aberration in conservative politics? As David Austin Walsh shows, the mainstream conservative movement and the far right have been intertwined for nearly a century, and both were born out of a “right-wing popular front” linking racists, anti-Semites, and fascists in a broad coalition opposed to socialism, communism, and New Deal liberalism. Far from being...
Messengers of the Right
Messengers of the Right tells the story of the media activists who built the American conservative movement and transformed it into one of the most significant and successful movements of the twentieth century—and in the process remade the Republican Party and the American media landscape.
Through These Blues
An account of the author's "thoughts on what I've seen happen across the American landscape and what I've experienced while squaring off with apologists and enablers for Islamic jihad, who operate inside American borders under the pretense of wanting to promote mutual understanding"--P. 4.
Encyclopedia of Beat Literature
Discusses the literary works and great authors of the Beat Generation.
