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Lipoprotein (A) Plasma Levels And Association To Cardiovascular Disease In A Stockholm County Cohort
Lipoprotein (a) plasma levels and association to cardiovascular disease in a Stockholm County cohort u2013 a retrospective observational cohort registry study Karin Littmann (1), MD, Jonas Brinck (2), MD, PhD, Mats Eriksson (2) MD, PhD, Paolo Parini (1,2), MD, PhD (1) Div. of Clinical Chemistry, Dept. of Laboratory Medicine, Karolinska Institutet and Function Area Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden(2) Metabolism Unit, Dept. of Medicine, Karolinska Institutet and Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme, Karolinska University Hospital, Stockholm SwedenAim: Lipoprotein(a) (Lp(a)) is a strong independent genetic risk factor for cardiovascular disease (CVD). At Lp(a) levels above 50 mg/dL, increased relative risk (1.46) for myocardial infarction (MI) and (1.95) for aortic stenosis (AS) has been reported (Afshar et.al. 2016). Whether reduction of Lp(a) leads to decreased risk is debated. Afshar et.al. estimated that 1 in 14 MI and 1 in 7 AS could be prevented by lowering Lp(a) to
Swedish Dissertations and their Subjects, 1600–1820 (Volume One)
This book challenges earlier understandings of early modern dissertations as unimaginative academic exercises. It argues for their continuous importance in scholarly and scientific discourse, and describes the richness and diversity of their subjects and themes. The book contains a complete catalogue of the almost 20,000 Swedish dissertations defended in Uppsala, Lund and Åbo, 1600 to 1820. The catalogue includes longer comments and descriptions of a few thousand of these dissertations, and also gives an analysis of how different subjects have evolved over time.
High-density Lipoprotein Function is Modulated by the SARS-CoV-2 Spike Protein in a Lipid-type Dependent Manner
Abstract: There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function diff...
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