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High-density Lipoprotein Function is Modulated by the SARS-CoV-2 Spike Protein in a Lipid-type Dependent Manner
Abstract: There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function diff...
Structure of Lipoproteins and Their Capacity for Lipid Exchange
Atherosclerosis, the largest killer in the western world, arises from build-up of plaques at the artery walls and can result in cardiovascular disease. Low- and high-density lipoproteins are involved in the disease development by depositing and removing lipids to and from macrophages at the artery wall. These processes are complex and not fully understood. Thus, determining the specific roles of the different lipoprotein fractions involved is of fundamental importance for the treatment of the disease. In this chapter, we present the state of the art in lipoprotein structure with focus on the comparison between normolipidemic and hypertriglyceridemic individuals. Then we discuss lipid transfe...
Management of Dyslipidemia
Dyslipidemia is a major risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. The earlier in life dyslipidemia is treated, the better the prognosis. The current book is an excellent one on dyslipidemia written by experts on this topic. This book includes 12 chapters including 5 on lipids, 4 on hypercholesterolemia in children, and 3 on the treatment of dyslipidemia. This book should be read by all health care professionals taking care of patients, including pediatricians since atherosclerotic cardiovascular disease begins in childhood.
Cognitive Pragmatics
An argument that communication is a cooperative activity between agents, who together consciously and intentionally construct the meaning of their interaction. In Cognitive Pragmatics, Bruno Bara offers a theory of human communication that is both formalized through logic and empirically validated through experimental data and clinical studies. Bara argues that communication is a cooperative activity in which two or more agents together consciously and intentionally construct the meaning of their interaction. In true communication (which Bara distinguishes from the mere transmission of information), all the actors must share a set of mental states. Bara takes a cognitive perspective, investi...
Sorghum
Sorghum is among the top five cereals and one of the key crops in global food security efforts. Sorghum is a resilient crop under high-stress environments, ensuring productivity and access to food when other crops fail. Scientists see the potential of sorghum as a main staple food in a future challenged by climate change. The contributors provide a comprehensive review of sorghum knowledge. The discussion covers genetic improvements, development of new hybrids, biotechnology, and physiological modifications. Production topics include water and nutrient management, rotations, and pest control. Final end uses, sorghum as a bioenergy crop, markets, and the future of sorghum are presented. IN PRESS! This book is being published according to the “Just Published” model, with more chapters to be published online as they are completed.
Euro Pop Book
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