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Renin, Aldosterone, the Aldosterone-to-renin Ratio, and Incident Hypertension Among Normotensive Subjects from the General Population
Abstract: Aims To investigate the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio [aldosterone-to-renin (ARR)] for incident hypertension in the general population. Methods and results Concentration of renin and aldosterone were measured by a chemiluminescence immunoassay using the fully automated LIAISON® platform (DiaSorin) among 5362 participants of the population-based Gutenberg Health Study, who were normotensive and had no clinically overt cardiovascular disease at baseline. During a follow-up period of 5 years, 18.6% (n = 996) developed a new-onset hypertension. Comparing extreme quartiles of biomarker distribution, the relative risk (RR...
Effects of Empagliflozin on Left Ventricular Diastolic Function in Addition to Usual Care in Individuals with Type 2 Diabetes Mellitus - Results from the Randomized, Double-blind, Placebo-controlled EmDia Trial
Abstract: Background The sodium-glucose co-transporter 2 inhibitor empagliflozin improves cardiovascular outcome in patients with type 2 diabetes mellitus (T2DM) and heart failure. Experimental studies suggest a direct cardiac effect of empagliflozin associated with an improvement in left ventricular diastolic function. Methods In the randomized, double-blind, two-armed, placebo-controlled, parallel group trial EmDia, patients with T2DM and elevated left ventricular E/E ́ ratio were enrolled and randomized 1:1 to receive empagliflozin 10 mg/day versus placebo. The primary endpoint was the change of left ventricular E/E ́ ratio after 12 weeks of intervention. Results A total of 144 patients...
Yorkshire Journal
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Sondersammlungen im 21. Jahrhundert
"Dieser Band ist das Ergebnis einer internationalen Tagung mit dem Titel 'Zwischen Kulturmanagement und Forschung: Sondersammlungen im 21. Jahrhundert' ..."; held Nov. 22-25, 2005, in Weimar--p. viii.
