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Multimodal Porphyrin-Based Conjugates
Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly effect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy called photodynamic therapy. In this thesis, the porphyrin structure has been synthetically combined with other molecule classes to achieve compounds with desirable multimodal characteristics. ...
Synthesis and application of ?-configured [18/19F]FDGs
Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachme...
The Behavioural Biology of Chickens
Chickens are by far the world’s most widely farmed animal, kept for both meat and egg production. They are at the centre of many debates regarding housing and production systems, causing significant interest in what lies behind chicken behaviour. This accessible book covers sensory biology, behavioural development, preferences and aversions, social behaviour, learning and cognition, behavioural issues in different systems and solutions for behavioural problems. Authored by an authority on chicken ethology, it brings together the fields of animal behaviour, neuroscience, psychology and epidemiology to provide a comprehensive understanding of chicken behaviour and help improve the lives of farmed chickens around the world.
An insight into the metabolism of New Psychoactive Substances
New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances across different drug groups. Many of these substances were originally developed for therapeutic use but have later appeared on the recreational drug market. The use of NPS has been associated with many outbreaks leading to hospitalizations and has been implicated in numerous fatalities worldwide. To be able to analytically detect drugs in a forensic setting is vital in the fight against the abuse of NPS. One of the most notable challenges in detection of NPS is the identification of major urinary metabolites for use as biomarkers. Furthermore, given the lack of reference standards in most metabolism studie...
Alternative Systems for Poultry
Recent interest in how poultry are housed and managed in order to ensure profitability, sustainability, and good levels of animal welfare, are challenging issues that commercial poultry keepers face, particularly where legislation is bringing about legal requirements for housing. This book compares and contrasts alternative housing with conventional and traditional systems for commercial poultry (laying hens, meat chickens, turkeys, waterfowl and gamebirds) with regards to welfare, disease, health, nutrition, sustainability and genotype-environment interaction.
White Savages -
A Historical Novel - George Washington/Native AmericansGeneral George Washington issued a directive to "Break the backs of the Iroquois" - the Nations of the N.E. natives who were impeding the progress of the land grabbers. This is the story of the Seneca tribe who lost not one life nor was one captured during 6000 troops chasing 6000 Senecas.The minister, Rev. Arden Lester, abruptly quits the pulpit after 25 years and two divorces. A conflict occurs with a powerful, but flawed, brother and sister of the Seneca tribes.The Senecas utilize an ancient "Medicine" - the ability to be "invisible" - because "aggressors cannot see clearly". White Savages is a political and spiritual quest to find an enemy, then conquer them - or heal with them.
Biohybrid Systems
The discipline of neurodesign is a highly interdisciplinary one, while at the same time in the process of maturing towards real-life applications. The breakthrough about to be achieved is to close the loop in communication between neural systems and electronic and mechatronic systems and actually let the nervous system adapt to the feedback from the man-made systems. To master this loop, scientists need a sound understanding of neurology, from the cellular to the systems scale, of man-made systems and how to connect the two. These scientists comprise medical scientists, neurologists and physiologists, engineers, as well as biophysicists. And they need the topics in a coherently written work with chapters building upon another.
Biology of Breeding Poultry
This book reviews the biological science and background to breeding meat poultry, specifically broiler, turkey and duck. These commercial birds have been changed by genetic selection to such an extent that they are substantially different from traditional breeds and laying hens. Covering science, management and husbandry systems, this book is an essential reference for researchers and students in animal science, as well as technical staff of breeding companies and poultry meat producers. Part of the Poultry Science Symposium Series.
Molybdenum and Tungsten Enzymes
There has been enormous progress in our understanding of molybdenum and tungsten enzymes and relevant inorganic complexes of molybdenum and tungsten over the past twenty years. This set of three books provides a timely and comprehensive overview of the field and documents the latest research. Building on the first and second volumes that focussed on biochemistry and bioinorganic chemistry aspects, the third volume focusses on spectroscopic and computational methods that have been applied to both enzymes and model compounds. A particular emphasis is placed on how these important studies have been used to reveal critical components of enzyme mechanisms. This text will be a valuable reference to workers both inside and outside the field, including graduate students and young investigators interested in developing new research programs in this area.
Behavioral Ecology of Neotropical Birds
This book covers central aspects of behavioral ecology, including sexual selection, social and genetic mating systems, cooperative breeding, brood parasitism, brood reduction, migration, personalities and communication. Over the past several years, Neotropical bird species from temperate to tropical latitudes of South America have been extensively studied, yielding valuable insights into the evolutionary mechanisms that drive their behavioral traits. In this book, international experts provide a general overview of main behavioral aspects. They also present the main findings of their work, including experimental approaches to testing the most accepted behavioral theory in their model systems. In closing, they propose new theoretical frameworks and future research directions. As such, the book provides a comprehensive and updated guide for all researchers, students and professionals whose work involves the study and management of birds across the Neotropical region.
