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With a thrilling narrative that sheds much light on recent events, this national bestseller brings to life the 1953 CIA coup in Iran that ousted the country’s elected prime minister, ushered in a quarter-century of brutal rule under the Shah, and stimulated the rise of Islamic fundamentalism and anti-Americanism in the Middle East. Selected as one of the best books of the year by the Washington Post and The Economist, it now features a new preface by the author on the folly of attacking Iran.
In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote...
First multi-year cumulation covers six years: 1965-70.
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As the aging population degree is deepened, cognitive impairment has become a globally recognized public health problem. As an intermediate state from normal cognition (NC) to Alzheimer's disease (AD), mild cognitive impairment (MCI) has a highly variable cognitive trajectory, which contains three outcomes: 1) progression to AD and other types of dementia; 2) Maintaining stability; 3) Reversal to NC. Reversal of cognitive function can be achieved by taking positive and effective measures. Current studies mostly focus on factors affecting MCI to AD. World Health Organization and Alzheimer’s Disease International have also proposed relatively mature guidelines for risk factors. However, ther...