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Molecular Genetic Pathology
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharma...
Early Netherlandish Paintings
"Any contemporary understanding of early Netherlandish paintings must take into account not only that historical data about them is fragmentary but also that art historians have used a variety of premises from which to study the works. This book, therefore, explores how the paintings of the period and the factual knowledge surrounding them have been assembled, analyzed, and interpreted from their rediscovery in the early nineteenth century to the present day." "Assembling these multiple perspectives in one volume, the editors underscore the common ground shared by their colleagues and intend thereby to advance the scholarly dialogue among them."--BOOK JACKET.
Breaking the Language Barrier
How do children learn their first words? The field of language development has been polarized by responses to this question. Explanations range from accounts that emphasize the importance of cognitive heuristics in language acquisition, to those that highlight the role of "dumb attentional mechanisms" in word learning. This monograph offers an alternative to these accounts. A hybrid view of word-learning, called the emergentist coalition theory, combines cognitive constraints, social-pragmatic factors, and global attentional mechanisms to arrive at a balanced account of how children construct principles of word learning. In twelve experiments, with children ranging from 12 to 25 months of age, data are described that support the emergentist coalition theory.
Ascorbic Acid in Plant Growth, Development and Stress Tolerance
Ascorbic acid (AsA), vitamin C, is one of the most abundant water-soluble antioxidant in plants and animals. In plants AsA serves as a major redox buffer and regulates various physiological processes controlling growth, development, and stress tolerance. Recent studies on AsA homeostasis have broadened our understanding of these physiological events. At the mechanistic level, AsA has been shown to participate in numerous metabolic and cell signaling processes, and the dynamic relationship between AsA and reactive oxygen species (ROS) has been well documented. Being a major component of the ascorbate-glutathione (AsA-GSH) cycle, AsA helps to modulate oxidative stress in plants by controlling ...
Qualitative approaches to research on plurilingual education / Enfocaments qualitatius per a la recerca en educació plurilingüe / Enfoques cualitativos para la investigación en educación plurilingüe
This handbook is a guide for researchers in plurilingual education. It introduces notions of collaborative research, action-research, ethnography, conversation analysis and mediated discourse analysis. It also discusses ethics, how to collect and organize plurilingual and multimodal corpora, and write up research papers.Aquest manual és una guia per a la recerca en educació plurilingüe. S'hi introdueixen conceptes de recerca col·laborativa, recerca-acció, etnografia, anàlisi de la conversa i anàlisi del discurs mediat. També s'hi discuteixen qüestions d'ètica, maneres de recopilar i organitzar corpus plurilingües i multimodals, i d’escriure textos de recerca.Este manual es una guía para la investigación en educación plurilingüe. Se introducen conceptos de investigación colaborativa, investigación-acción, etnografía, análisis de la conversación y análisis del discurso mediado. También se discuten cuestiones de ética, maneras de recopilar y organizar corpus plurilingües y multimodales, y de redactar textos de investigación.
Oxidative Stress and Neurodegenerative Disorders
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Spain, the Unfinished Revolution
"The Spanish Civil War was fought from 17 July 1936 to 1 April 1939 between the Republicans, who were loyal to the established Spanish Republic, and the Nationalists, a rebel group led by General Francisco Franco. The Nationalists prevailed, and Franco ruled Spain for the next 36 years, from 1939 until his death in 1975."--Wikipedia.
