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Proteases: Structure and Function
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role ...
Activation of Viruses by Host Proteases
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
Moral Capitalism
The world is drifting without a clear plan for its economic development. Communism is dead, but in the wake of Enron and similar scandals, many see capitalism as amoral and too easily abused. A blueprint for progress is needed and Moral Capitalism provides one. Moral Capitalism is based on principles developed by the Caux Round Table, an extraordinary international network of top business executives who believe that business can-and must-weigh both profit and principle. Caux Round Table's global chair, Stephen Young, argues that the ethical standards inherent in capitalism have been compromised by cultural values inimical to capitalism's essentially egalitarian, rational spirit, and distorted by the short-sighted dog-eat-dog doctrines of social Darwinism into what he calls brute capitalism. He demonstrates how the Caux Round Table's Seven General Principles for Business can serve as a blueprint for a new moral capitalism, and explores in detail how, if guided by these principles, capitalism is really the only system with the potential to reduce global poverty and tyranny and address the needs and aspirations of individuals, societies, and nations.
Through the Looking Glass
Through the Looking Glass provides a detailed and comprehensive study of the writer's memoir and an exploration of the genre's poetics. It presents the critical history of memoir and develops its own definition of the genre by focusing on such markers as phantasmatism of the pact between writer and reader, (auto)biographism of the space inhabited by the text, syllepsism of the subject, detotalization in terms of scope, and thematic content. The study also proposes an original typology of fifteen micro-genres of memoir (souvenirs d'enfance, souvenirs d'adolescence, falling away memoir, memoirs/scenes from life, patriography, matriography, parental memoir, autrememoir, pet memoir, [auto]pathography, [auto]thanatography, travelogue, periegetic memoir, ekphrastic memoir, and bibliomemoir). Out of over forty memoirs addressed by this study, five writers' memoirs (by Andrew Motion, Rachel Cusk, Hilary Mantel, Julian Barnes, and J.M. Coetzee, respectively) are addressed in greater detail and thus acknowledged as the genre's prime specimens.
The Travellers
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Sex and Gender Differences in Pharmacology
This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.
Between the Devil and the Host
For the first time in English, Michael Ostling tells the story of the imagined Polish witches, showing how ordinary peasant-women got caught in webs of suspicion and accusation, finally confessing under torture to the most heinous of crimes.
You Have Words of Eternal Life
The highly-respected Swiss theologian provides short, profound meditations on numerous scriptural passages throughout the New Testament. The simplicity and wisdom of these meditations demonstrates that, although he was a great theologian, von Balthasar was deeply interested in sustaining the spiritual lives of modern men and women in this difficult time of the Church. "These beautiful meditations of Fr. von Balthasar are a wonderful testament to his spirit-a spirit of great love of the Lord and his Church, and a spirit of the deepest wisdom and discernment for our times. Turn wherever you like in these pages and I believe you will find the spiritual nourishment which our souls need so much t...
Optically Stimulated Luminescence Dosimetry
Optically Stimulated Luminescence (OSL) has become the technique of choice for many areas of radiation dosimetry. The technique is finding widespread application in a variety of radiation dosimetry fields, including personal monitoring, environmental monitoring, retrospective dosimetry (including geological dating and accident dosimetry), space dosimetry, and many more. In this book we have attempted to synthesize the major advances in the field, covering both fundamental understanding and the many applications. The latter serve to demonstrate the success and popularity of OSL as a dosimetry method. The book is designed for researchers and radiation dosimetry practitioners alike. It delves i...
