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The core purpose of social enterprise is to create value for the betterment of society. This aim lies at the center of the framework and is the end toward which all other elements in the framework must contribute. Greater alignment of these elements with the central purpose produces higher organizational coherence which contributes to superior performance.
The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic optio...
Cardiologists must answer three important questions when evaluating and treating patients with a coronary artery stenosis. As a physiologist: "What is the effect of this stenosis on coronary blood flow and myocardial function?"; as a clinician: " Is this lesion responsible for the patient's symptoms?"; and finally as an interventionalist: "Will revascularization of this artery improve the patient?" Fundamentally, the answer to these questions can be given to a large extent by measuring coronary pressure. That is the rationale of writing this book. 1. 1 Historical overview. Andreas Gruentzig and most interventional cardiologists in the early days of PTCA, had the intuitive feeling that pressu...
Based on a groundbreaking study, analysing data on 200 management practices gathered over a 10 year period. Reveals the effectiveness of the 4+2 practices (4 primary and 2 of 4 possible secondary) practices that really matter –– the ones that, if followed rigorously, ensure sustained business success. With a new introduction by the authors. With hundreds of well–known management practices and prescriptions promoted by consultants and available to business, which are really effective and contribute to the growth and continued success of a company? Which do little or nothing? Based on the "Evergreen Project," a massive, 5 year study involving the business school faculties of ten universities, the authors set out to find the management practices that truly promote long–term growth and success. Their findings will revolutionize the art and practice of business management.The book shows that there are essentially six management practices that all successful companies must master simultaneously. They range from focusing on a strategy of growth to maintaining the depth and quality of human talent in the organization.
Oscar is a small sloth who loves wearing pink clothes. He's not like many others in his funky town. His friends and family may think, act and look differently than him, but in the end, he learns the most important quality of all is within him. Written and illustrated Carlee Reid, a co-creator of "I Love My Kinky Hair", the labor of love "Oscar Wears Pink Clothes" reflects the narratives of the young and unique, hoping to bring them to appreciate what is within.
The children of the past decade's influx of immigrants comprise a second generation far different than any this country has known before. Largely non-white and from the world's developing nations, these children struggle with complex problems of racial and ethnic relations in multicultural urban neighborhoods, attend troubled inner city schools, and face discriminatory labor markets and an economy that no longer provides the abundant manufacturing jobs that sustained previous generations of immigrants. As the contributors to The New Second Generation make clear, the future of these children is an open question that will be key to understanding the long-range consequences of current immigrati...
An American supermarket and a Mexican food bank, an Argentine newspaper and a solidarity network, a Chilean pharmacy chain and an elder care home: the authors analyze why and how such social partnering occurs and provide a compelling framework for identifying key levers that maximize value creation for participants and society.
The interventional cardiologist has to tackle a diverse and complex range of coronary lesions. For this reason, the experts who compiled this volume contribute the best practices for overcoming plaque and thrombus in the coronary arteries. From simple to complicated anatomy, the direct approach to achieving optimal results is clearly described and illustrated. Each chapter focuses on a specific problem, and top quality angiograms illustrate the various coronary lesions. The editors, all experts and pioneers in the field of interventional cardiology, from stenting to myocardial revascularization, have assembled a team of internationally renowned contributors to offer their practical advice on how to approach lesions in a straight-forward, pragmatic fashion. This guide is indispensable for cardiologists and students of the field, as well as for general practitioners.