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The Metabolic Pathway Engineering Handbook
This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction
Current Challenges in Modeling Cellular Metabolism
Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the s...
The Metabolic Pathway Engineering Handbook, Two Volume Set
Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab
Biomass for Bioenergy and Biomaterials
Biomass for Bioenergy and Biomaterials presents an overview of recent studies developed specifically for lignocellulose-based production of biofuels, biochemicals, and functional materials. The emphasis is on using sustainable chemistry and engineering to develop innovative materials and fuels for practical applications. Technological strategies for the physical processing or biological conversion of biomass for material production are also presented. FEATURES Offers a comprehensive view of biomass processing, biofuel production, life cycle assessment, techno-economic analysis, and biochemical and biomaterial production Presents details of innovative strategies to pretreat biomass Helps read...
Aspergillus and Penicillium in the Post-genomic Era
Genome sequencing has affected studies into the biology of all classes of organisms and this is certainly true for filamentous fungi. The level with which biological systems can be studied since the availability of genomes and post-genomic technologies is beyond what most people could have imagined previously. The fungal genera Aspergillus and Penicillium contain some species that are amongst the most widely used industrial microorganisms and others that are serious pathogens of plants, animals and humans. These genera are also at the forefront of fungal genomics with many genome sequences available and a whole genus genome sequencing project in progress for Aspergillus. This book highlights...
Heterologous Protein Production in CHO Cells
This volume discusses protocols that cover genetic manipulation of Chinese hamster ovary (CHO) cells for recombinant protein production, and protocols for the characterization of CHO cells using ‘omic approaches. This book also explores methods that discuss the genome editing tool, CRISPR/Cas9, and the characterization of recombinant protein products, such as glycosylation and host cell protein analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Heterologous Protein Production in CHO Cells: Methods and Protocols is a valuable resource for scientists and researchers who are interested in further studying cell production in CHO cells.
Systems Metabolic Engineering
Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.
Lay Prophets in Lutheran Europe (c. 1550–1700)
Lay prophets in Lutheran Europe (c. 1550–1700) is the first transnational study of the phenomenon of angelic apparitions in all Lutheran cultures of early modern Europe. Jürgen Beyer provides evidence for more than 350 cases and analyses the material in various ways: tracing the medieval origins, studying the spread of news about prophets, looking at the performances legitimising their calling, noting their comments on local politics, following the theological debates about prophets, and interpreting the early modern notions of holiness within which prophets operated. A full chronology and bibliography of all cases concludes the volume. Beyer demonstrates that lay prophets were an accepted part of Lutheran culture and places them in their social, political and confessional contexts.
Jews and Christians in Denmark
In Jews and Christians in Denmark: From the Middle Ages to Recent Times, ca. 1100–1948, Martin Schwarz Lausten investigates how the Church and society followed the European antijudaistic tradition using insults, adversities and attempted conversions during Catholic times from around 1100 and Protestant times starting around 1536. In spite of the tolerant policies of integration initiated by the government beginning in the 1800’s, anti-Semitic movements arose among priests, professors and local authorities. However, during the German occupation (1940–1945) priests and many others assisted the 7,000 Danish Jews in their escape to Sweden. Based on Jewish and Christian sources, Jewish reactions to life in Denmark are also examined.
