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Wine and Vine Components and Health
While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing for the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis represent adaptable plants, and thanks to the large variety of strains, wine is an alchemical mix with unique properties, a rich and original composition in terms of polyphenols, and well known antioxidants. This explains why wine and health are closely linked to nutrition.
Dynamics of Membrane Proteins and Cellular Energetics
This manual on "Dynamics of Membrane Proteins and Cellular Energetics" is the result of a FEBS-CNRS Course held in Grenoble and Besanc;{on in September 1987.' It appears to be, after the first, published in 1979 the fifth of the series. After focussing on the "Biochemistry of Membranes" (1979) it was the turn of "Membrane Proteins" (1981) and of Enzymes, Receptors and Carriers of Biological Membranes (1983), fo1- wed by "Membrane Proteins Isolation and Characterization" ( 1986) . Al though the central issue has always been the its components and its functions, each biological membrane, manual has put the accent on somewhat different issues corresponding to the most innovative, interesting re...
Peroxisomes
Discovered and first isolated in 1966 in C. De Duve's laboratory, peroxisomes - organelles which are present in nearly all eukaryotic cells - are still not fully understood. More than 40 peroxisomal enzymes catalyzing a variety of reactions have been characterized. Moreover, peroxisomes can be regarded as toxicological indicators: several compounds, including hypolipemic drugs, plasticizers or pesticides trigger their proliferation. This proliferation may lead to hepatocarcinogenesis in rodents. Interest in peroxisomes stems not only fromtheir biology, but also because there is a deficiency of peroxisomal functions in several genetic diseases. Some genes involved in inborn errors of peroxiso...
Recent Advances in Redox Active Plant and Microbial Products
Nature endows us with a treasure chest of Green Gold full of amazing ‘redox-active’ substances which interfere with numerous biological processes in our own body, in animals, bacteria, fungi and plants. Whilst such natural products are all around and also in us, we still do not fully understand how these compounds actually work. This book attempts to resolve some of the mysteries and riddles associated with such products. Written by more than thirty international experts from academia and industry, it places a focus on modern developments in this field and considers such natural products from various angles, from their isolation and characterization all along to product development and commercialization. Throughout, the reader will be confronted with modern approaches which enable the efficient identification and isolation of new natural products, help to elucidate their mode(s) of action and permit practical uses in Medicine, Cosmetics, Agriculture, Industry and as functional foods.
Implication of Oxysterols and Phytosterols in Aging and Human Diseases
This book provides basic knowledge of the biology, chemistry, and function of oxysterols and its derivatives as well as of phytosterols in numerous human diseases. The book is divided into six sections and begins with an introduction to the biological and chemical properties of oxysterols and its derivatives as well as phytosterols, their synthesis, and the methods currently used for their detection in various biospecimens. The following section discusses in detail the various effects of oxysterols on numerous human diseases, including infectious diseases, inflammatory and autoimmune diseases, atherosclerosis, and cancer, as well as neurological and neuropsychiatric disorders. Importantly, t...
Bioactive Compounds from Natural Sources, Second Edition
The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other rel...
From Natural Polyphenols to Synthetic Bioactive Analogues
This Special Issue is focused on natural polyphenols and their synthetic bioactive analogues. It is composed of one review on aza- and azo-stilbenes as bioisosteric analogs of the stilbenoid resveratrol and four original articles, including studies on synthetic (bisphenol neolignans inspired by honokiol, multicomponent synthesis of polyphenols), and natural polyphenols (polyphenols from Tamarix ramosissima and Melanoleuca styphelioides) as antiproliferative, anti-Alzheimer’s, antioxidant, antimicrobial, or anti-inflammatory agents.
Advances in Molecular Toxicology
Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Work...
Structure, Chemical Analysis, Biosynthesis, Metabolism, Molecular Engineering and Biological Functions of Phytoalexins
This book is a printed edition of the Special Issue "Structure, Chemical Analysis, Biosynthesis, Metabolism, Molecular Engineering and Biological Functions of Phytoalexins" that was published in Molecules
Studies on Experimental Toxicology and Pharmacology
This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology. Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders. With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.
