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From Obesity to Diabetes
Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.
Computational and Experimental Protein Variant Interpretation in the Era of Precision Medicine
One of the key goals in the postgenomic era is the elucidation of the mechanisms underlying the relationship between genotype and phenotype. In particular, understanding how human genetic and somatic variations are associated with diseases is still an open problem and its solution is a crucial issue for exploiting the possibilities offered by the modern sequencing techniques in the framework of precision and personalized medicine. The increasing amount of data generated by the sequencing initiatives calls for accurate and reliable computational approaches to predict the impact of mutations on the phenotype, and possibly for methods to correlate them with diseases. From the experimental point of view, disease-causing variants are supposed to directly affect protein function, protein stability as well as the kinetics and thermodynamics of protein-protein recognition, and robust validation at the molecular scale is necessary. This approach can be of invaluable help in facing new challenges such as the fast development of effective vaccines.
Trusted Cloud Computing
This book documents the scientific results of the projects related to the Trusted Cloud Program, covering fundamental aspects of trust, security, and quality of service for cloud-based services and applications. These results aim to allow trustworthy IT applications in the cloud by providing a reliable and secure technical and legal framework. In this domain, business models, legislative circumstances, technical possibilities, and realizable security are closely interwoven and thus are addressed jointly. The book is organized in four parts on “Security and Privacy”, “Software Engineering and Software Quality”, “Platforms, Middleware and Integration”, and “Social Aspects, Busine...
Handbook of Research on the Impact of Culture and Society on the Entertainment Industry
"This reference provides a review of the academic and popular literature on the relationship between communications and media studies, cinema, advertising, public relations, religion, food tourism, art, sports, technology, culture, marketing, and entertainment practices"--Provided by publisher.
Novel Approaches to Urban Design and Architecture Education: Design Studio Practice and Pedagogy
A significant challenge has arisen as the way people interact with their environments undergoes significant changes, requiring crucial adjustments to existing environments, design methods, and educational systems. The relationship between these elements forms the backdrop for a complex challenge faced by academic scholars and design professionals alike. As the backbone of design education, design studios operate as microcosms, each with their unique interpretation of ongoing changes and distinctive approaches to solving real-world problems. This evolving landscape prompts a pivotal question: How can the varied pedagogies within design education be curated and explored to foster a more compre...
