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Delayed Injury Mechanisms After Ischemic and Hemorrhagic Stroke
Topic Editor, Dr. Devin McBride, received financial support from Celense. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The Peter Principle
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Stereotactic Cisternal Lavage in Patients with Aneurysmal Subarachnoid Hemorrhage with Urokinase and Nimodipine for the Prevention of Secondary Brain Injury (SPLASH): Study Protocol for a Randomized Controlled Trial
Abstract: Background Delayed cerebral infarction (DCI) is a major cause of death and poor neurological outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). Direct intrathecal therapies with fibrinolytic and spasmolytic drugs have appeared promising in clinical trials. However, access to the subarachnoid space for intrathecal drug administration is an unsolved problem so far, especially in patients with endovascular aneurysm securing. We investigate a therapy protocol based on stereotactic catheter ventriculocisternostomy (STX-VCS), a new approach to overcome this problem. The primary objective of this study is to assess whether cisternal lavage with urokinase, nimodipine, and ...
Peter Churcher
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Peter Churcher
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