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Bacterial Genomes and Infectious Diseases
The first bacterial genome, Haemophilus influenzae, was completely sequenced, annotated, and published in 1995. Today, more than 200 prokaryotic (archaeal and bacterial) genomes have been completed and over 500 prokaryotic genomes are in va- ous stages of completion. Seventeen eukaryotic genomes plus four eukaryotic chro- somes have been completed. The concept of achieving better understanding of an organism through knowledge of the complete genomic sequence was first demonstrated in 1978 when the first bacteriophage genome, X174, was sequenced. Complete genomic sequences of prokaryotes have led to a better understanding of the biology and evolution of the microbes, and, for pathogens, facil...
Bruce Lee The Chan Yuk Collection Variant 2 Landscape Edition
Chan Yuk - The man who Shot Bruce Lee Variant 2 Landscape edition (2021) This is a special edition hardback book, this will be a limited edition.Chan Yuk is the man responsible for many of the photographs we see of Bruce Lee.He is the man who shot Bruce Lee - with his cameraAmong fans he is a bit of an Enigma as rarely do we see his face but his photographs adorn walls and books worldwide.This is a variant version of the A4 release (2020) presented in a Landscape format printed in a high resolution for best picture quality 100 pages and 180 photographs taken from both behind the scenes and on set from all Bruce Lee's movies To most Bruce Lee fans, Chan Yuk is a bit of an enigma. He is the ma...
Medical Imaging Informatics
Medical Imaging Informatics provides an overview of this growing discipline, which stems from an intersection of biomedical informatics, medical imaging, computer science and medicine. Supporting two complementary views, this volume explores the fundamental technologies and algorithms that comprise this field, as well as the application of medical imaging informatics to subsequently improve healthcare research. Clearly written in a four part structure, this introduction follows natural healthcare processes, illustrating the roles of data collection and standardization, context extraction and modeling, and medical decision making tools and applications. Medical Imaging Informatics identifies core concepts within the field, explores research challenges that drive development, and includes current state-of-the-art methods and strategies.
PARP Inhibitors for Cancer Therapy
PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
Queer Japanese
Abe presents a comprehensive picture of the linguistic strategies employed by Japanese sexual minorities in various social contexts, from magazine advice columns to bars to text messaging on cell phones to private homes.
