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The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in IPSC and Fly Models of Parkinson's Disease
Abstract: While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate age-related metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD. Our findings suggest NR as a viable clinical avenue for neuroprotection in PD and other neurodegenerative diseases
Architecture and Design: Breakthroughs in Research and Practice
Technological evolutions have changed the field of architecture exponentially, leading to more stable and energy-efficient building structures. Architects and engineers must be prepared to further enhance their knowledge in the field in order to effectively meet new and advancing standards. Architecture and Design: Breakthroughs in Research and Practice is an authoritative resource for the latest research on the application of new technologies and digital tools that revolutionize the work of architects globally, aiding in architectural design, planning, implementation, and restoration. Highlighting a range of pertinent topics such as design anthropology, digital preservation, and 3D modeling, this publication is an ideal reference source for researchers, scholars, IT professionals, engineers, architects, contractors, and academicians seeking current research on the development and creation of architectural design.
Reasoning, Action and Interaction in AI Theories and Systems
The present book is a festschrift in honor of Luigia Carlucci Aiello. The 18 articles included are written by former students, friends, and international colleagues, who have cooperated with Luigia Carlucci Aiello, scientifically or in AI boards or committees. The contributions by reputed researchers span a wide range of AI topics and reflect the breadth and depth of Aiello's own work.
Vét de Sol
"Il titolo dell'opera, Vét de Sol, implica un viatico romantico, simbolico ed evocativo: il nome di un vento che trasporti questi componimenti in fuga, verso altri territori, altre culture, lettori, autori. All'interno di Vét de Sol (come in Emilia Romagna chiamano il vento di Levante, vento fresco e umido, che si origina nel centro del Mediterraneo al largo delle Isole Baleari) si susseguono, in ordine alfabetico: Giacomo Curatolo con 'L'imperfetto', Tommaso de Cataldo con 'Solstizio', Lucia De Cicco con 'Un biglietto per l'Inferno', Claudio Foresti con 'Oltre le stagioni... Al di là dei confini', Silvia Lodi con 'Voli di Lisa', Barbara Regazzoni con 'Anima Madre'." (Tratto dalla Prefazione di Giuseppe Aletti)
The Undersea Journal
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Computer Safety, Reliability, and Security
This book constitutes the refereed proceedings of 5 workshops co-located with SAFECOMP 2015, the 34th International Conference on Computer Safety, Reliability, and Security, held in Delft, The Netherlands, in September 2015. The 36 revised full papers presented were carefully reviewed and selected from numerous submissions. This year’s workshop are: ASSURE 2015 - Assurance Cases for Software-intensive Systems; DECSoS'15 - EWICS/ERCIM/ARTEMIS Dependable Cyber-physical Systems and Systems-of-Systems Workshop; ISSE'15 - International workshop on the Integration of Safety and Security Engineering; ReSA4CI 2015 - International Workshop on Reliability and Security Aspects for Critical Infrastructure Protection; SASSUR 2015 - International Workshop on Next Generation of System Assurance Approaches for Safety-Critical Systems.
Digital Transformation for Fashion and Luxury Brands
Zusammenfassung: This book re-evaluates the diffusion and positioning of fashion and luxury brands following the impact and disruption of digital transformations, particularly on existing omni-channel models and touchpoints and consumer behaviours. By exploring the importance of digital transformation and discussing the benefits and challenges it has created for the fashion industry, this book provides insights into the role of various digital technologies, systems and strategies in generating and maintaining brand value and equity, customer engagement and experiences and connecting the marketplace and marketspace. Wilson Ozuem teaches and supervises research projects in a number of UK unive...
