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Gliomas
Gliomas, which comprise astrocytic, oligodendroglial, and ependymal lesions, are the most frequent primary intracranial tumors. This volume summarizes the enormous advances in our knowledge of gliomas that have occurred during recent years. The first part of the book focuses on the glial tumor entities, with detailed discussion of diagnosis, molecular genetics, and tumor origin. This section also contains a chapter on hereditary tumor syndromes associated with gliomas and the molecular mechanisms underlying these specific diseases. The second part is devoted to the clinical management of gliomas and provides insights into novel developments regarding neuroimaging, surgical management, radiation therapy, adjuvant therapy, experimental approaches, and the neurotoxicity of treatment. The final part of the book addresses angiogenesis and epigenetic regulation of gene expression in gliomas.
A Mist Connection
In the summer of 1783, an unusual dry fog descended upon large parts of the northern hemisphere. The fog brought with it bloodred sunsets, a foul sulfuric odor, and a host of other peculiar weather events. Inspired by the Enlightenment, many naturalists attempted to find reasonable explanations for these occurrences. Between 8 June 1783 and 7 February 1784, a 27-kilometer-long fissure volcano erupted in the Icelandic highlands. It produced the largest volume of lava released by any volcanic eruption on planet Earth in the last millennium. In Iceland, the eruption led to the death of one-fifth of the population. The jetstream carried its volcanic gases further afield to Europe and beyond, whe...
Molecular Pathology of Nervous System Tumors
This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
Encyclopedia of Molecular Mechanisms of Disease
This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.
The Landscape of Genomic Alterations Across Childhood Cancers
Abstract: Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7-8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials
TelomereHunter
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Climate and Society in Europe
A richly illustrated book on the history of climate change in Europe. Two perspectives, one unique book: two leading experts, a historian and a climatologist, co-author a new standard work on climate history. An overview of the connection between climatic and social developments over the last 1000 years. For the first time, a historian and a climatologist with knowledge of climate history have worked closely together to create a unique book, combining climate reconstructions based on documented data in their human-historical context with temporally highly resolved analyses of climate and glaciers. "Here we can clearly see how changes in climate affected the environment and people of Europe o...
Women in Prisons
In this eye-opening book, the author sheds light on the often-ignored issue of women's incarceration and the many factors that contribute to it. From hormone imbalances and mental health issues to systemic flaws in the criminal justice system, this book explores the multifaceted challenges that women face when it comes to being incarcerated and staying out of prison. Drawing on the latest research and expert perspectives, the author offers insights into what can be done to improve the lives of women behind bars and reduce recidivism rates. The book covers a range of topics, including the role of hormones in women's mental health, the impact of poverty and trauma on drug abuse, and the need for reform in law enforcement and judicial systems. With its compassionate and thought-provoking approach, this book is a must-read for anyone interested in criminal justice reform, women's health, and social justice issues. It challenges readers to think critically about the way our society treats incarcerated women and offers practical solutions for creating a more just and equitable system.
