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Deep Learning Based Automated Delineation of the Intraprostatic Gross Tumour Volume in PSMA-PET for Patients with Primary Prostate Cancer
Abstract: Purpose With the increased use of focal radiation dose escalation for primary prostate cancer (PCa), accurate delineation of gross tumor volume (GTV) in prostate-specific membrane antigen PET (PSMA-PET) becomes crucial. Manual approaches are time-consuming and observer dependent. The purpose of this study was to create a deep learning model for the accurate delineation of the intraprostatic GTV in PSMA-PET. Methods A 3D U-Net was trained on 128 different 18F-PSMA-1007 PET images from three different institutions. Testing was done on 52 patients including one independent internal cohort (Freiburg: n = 19) and three independent external cohorts (Dresden: n = 14 18F-PSMA-1007, Boston:...
Pattern
As models and paradigms, patterns have been helping to orient architects since the Middle Ages. But patterns are also the basis of the history of ornament, an aesthetic phenomenon that links all times and cultures at a fundamental level. Ornament – and hence pattern as well – was abolished by the avant-garde in the first half of the twentieth century, but the notion of pattern has taken on new meaning and importance since the 1960s. Complexity research has ultimately shown that even highly complex, dynamic patterns may be based on simple behavioral rules, and that has allowed the notions of pattern and pattern formation to take on new meanings, that are also central for architecture. Today the use of generative computerized methods is opening up new ways of talking about an idea that is becoming increasingly abstract and dynamic. Pattern explores the question: what are the notions of pattern that must be discussed in the context of contemporary architecture?
Information Design
Information Design provides citizens, business and government with a means of presenting and interacting with complex information. It embraces applications from wayfinding and map reading to forms design; from website and screen layout to instruction. Done well it can communicate across languages and cultures, convey complicated instructions, even change behaviours. Information Design offers an authoritative guide to this important multidisciplinary subject. The book weaves design theory and methods with case studies of professional practice from leading information designers across the world. The heavily illustrated text is rigorous yet readable and offers a single, must-have, reference to anyone interested in information design or any of its related disciplines such as interaction design and information architecture, information graphics, document design, universal design, service design, map-making and wayfinding.
Spatial Cognition V
This book constitutes the refereed proceedings of the International Conference on Spatial Cognition, Spatial Cognition 2006. It covers spatial reasoning, human-robot interaction, visuo-spatial reasoning and spatial dynamics, spatial concepts, human memory, mental reasoning and assistance, spatial concepts, human memory and mental reasoning, navigation, wayfinding and route instructions as well as linguistic and social issues in spatial knowledge processing.
Spatial Cognition
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Ökumenisches Kompendium Caritas und Diakonie
Caritas und Diakonie sind für die Kommunikation des Evangeliums in Wort und Tat zentral. Sie beschreiben eine Grundhaltung der Achtsamkeit für Leid und des Eintretens für Menschen in Not. Zugleich stehen sie für das organisierte soziale Engagement der beiden großen Kirchen. In 57 Artikeln befassen sich Fachleute aus Wissenschaft, Wohlfahrtsverbänden und Kirchen mit den Erscheinungsformen und Herausforderungen von Diakonie und Caritas. In den Blick kommen auch Hilfepraxen, die jüdische oder islamische Prägungen haben oder menschenrechtlich begründet sind. Traditionen diakonischen Handelns werden ebenso dargestellt wie Diskurse um die Weiterentwicklung des Sozialen sowie exemplarische Handlungsfelder. Das Kompendium will dazu beitragen, kirchlich-soziale Verantwortung deutlich kooperativer zu gestalten und den Dialog mit Akteurinnen und Akteuren unterschiedlicher Prägung zu intensivieren. Das macht es zu einem einzigartigen Handbuch für Studium und Praxis.
Internal Investigations
Erstmals für den deutschen Rechtskreis führt das umfassend angelegte Handbuch die allgemeinen rechtlichen Grundlagen und Anforderungen an unternehmensinterne Aufklärungsmaßnahmen („Internal Investigation“) mit praxiserprobten Darstellungen der für Wirtschaftsunternehmen aller Branchen relevanten Fachgebiete zusammen. Im ersten Teil werden sämtliche grundlegenden Querschnittsthemen wie gesellschafts- und arbeitsrechtliche Grundlagen, Anforderungen an Art und Umfang einer Internal Investigation – auch grenzüberschreitend – aufbereitet. Einen für den Praktiker besonderen Reiz haben Kapitel über die Planung und Organisation der Investigation, die Dokumentenanalyse, die Datenaufb...
