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New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Italian Fashion since 1945
In the course of the twentieth century, Italy succeeded in establishing itself as one of the world's preeminent fashion capitals, despite the centuries-old predominance of Paris and London. This book traces the story of how this came to be, guiding readers through the major cultural and economic revolutions of twentieth-century Italy and how they shaped the consumption practices and material lives of everyday Italians. In order to understand the specific character of the “Italian model,” Emanuela Scarpellini considers not only aspects of craftsmanship, industrial production and the evolution of styles, but also the economic and cultural changes that have radically transformed Italy and the international scene within a few decades: the post-war economic miracle, the youth revolution, the consumerism of the 1980s, globalization, the environmentalism of the 2000s and the Italy of today. Written in a lively style, full of references to cinema, literature, art and the world of media, this work offers the first comprehensive overview of a phenomenon that has profoundly shaped recent Italian history.
IL-1 Inhibition
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
La provvidenza rossa
L’omicidio di una militante del Partito. Il meccanismo a orologeria del Pci. La vorticosa e caotica Milano degli anni Settanta. Questo romanzo è un mistery, sono inventati il crimine che scatena la vicenda, la trama, e la soluzione finale, e sono fittizi i protagonisti; ma è pure un pezzo importante di memoria, come forse sarebbe difficile riportare con la stessa evidenza in un saggio di storia. La memoria di cosa fu un grande partito, di come funzionava la mente di dirigenti e militanti, di come si muoveva l’invisibile macchina del potere e del contropotere in una grande metropoli negli anni fine Settanta, poco prima che l’omicidio Moro scompigliasse la storia d’Italia.
L'altra agricoltura
372.10
