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Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studi...
This book presents a collection of twelve interviews with eminent English contemporary writers held during a period of four years. The book allows an illuminating insight into a very lively and thought-provoking literary culture, stirred not only by recent ideas of postmodernism but also by the manifold issues of nationality, culture, and gender subjected to permanent redefinitions towards the end of the twentieth century. The interviews with Peter Ackroyd, John Banville, Julian Barnes, Alain de Botton, Maureen Duffy, Tibor Fischer, John Fowles, Romesh Gunesekera, Tim Parks, Terry Pratchett, Jane Rogers, and Adam Thorpe cover topics such as the relationship between writer and public, the role of the literary tradition, the relevance of contemporary literary theory for the production of literature, images of nationality, intertextuality, changes in the attitude towards language and meaning, and the reception of literary texts by critical reviewers and literary critics.
Mit sanfter Berührung zum hormonellen Gleichgewicht In der alternativen Naturheilkunde und komplementären Gynäkologie hat sich die TFM (Therapeutische Frauen-Massage) seit Jahren bewährt. Die sanfte, ganzheitliche Öl-Massage ist integrativer Bestandteil zum Herstellen des hormonellen Gleichgewichts und unterstützt viele weitere Themen des Frau-Seins. In verständlichen Schritt-für-Schritt Anleitungen findest Du die Handgriffe für die Massage erklärt. Durch anschauliche Illustrationen und Fotos ist die TFM einfach umsetzbar. Der große Ratgeber-Teil beleuchtet Krankheitsbilder wie Menstruationsschmerzen, Endometriose, Myome, Senkungsbeschwerden und dient der gynäkologischen Begleittherapie. Anleitungen zur Eigenmassage unterstützen die Therapie zusätzlich. Mit der TFM hast Du eine hilfreiche und wirksame Wegbegleitung durch dein eigenes Frauenleben und das deiner Patientinnen gefunden: stimmige Behandlungen, die gleichzeitig Körper, Geist und Seele berühren, die eigene Mitte spüren lassen und Gewebe und Organe vitalisieren.
Architecture Rausch opens discussion on architectural training in this volatile time, and who better to articulate those challenges (as well as to challenge the limits of the profession) than the students who will face them in the twenty-first century? The book presents works by students from a studio at Technische Universität Berlin (TU Berlin), Germany's largest science and engineering school. Among the editors are faculty members whose cutting-edge work includes the Gallery for Contemporary Art Leipzig and projects with Daniel Libeskind.
As much as dogs, cats, or any domestic animal, horses exemplify the vast range of human-animal interactions. Horses have long been deployed to help with a variety of human activities—from racing and riding to police work, farming, warfare, and therapy—and have figured heavily in the history of natural sciences, social sciences, and the humanities. Most accounts of the equine-human relationship, however, fail to address the last few centuries of Western history, focusing instead on pre-1700 interactions. Equestrian Cultures fills in the gap, telling the story of how prominently horses continue to figure in our lives, up to the present day. Kristen Guest and Monica Mattfeld place the m...
Features: The White Tops by Ken Wheeling - Page 79 The Wheeler Survey in Nevada: The Odometer Carriage - Page 92 Music to My Ears by William Stewart - Page 104 Additional Articles: 2018 International Carriage Symposium The Brewster Project by Merri Ferrell - Page 70 On Location in Arizona by Trish Demers - Page 72 NER/CAA Learning Weekend by Kristen W. Retter - Page 74 Driving the Horse in Harness: A Beginner's Manual - Part V by Charles Kellogg - Page 84 Conserving A Mitchell Farm Wagon by Jerry and Laurie Bowman - Page 92 Some Faults of Harness Horses by Tom Ryder - Page 96 Horse-seining by Gregory Cuffey - Page 128
NATIONAL BESTSELLER • “A vivid portrait of America’s greatest stallion, the larger-than-life men who raced and bred him, and the dramatic times in which they lived.”—Geraldine Brooks, author of Horse The powerful true story of the champion Thoroughbred racehorse who gained international fame in the tumultuous Civil War–era South, and became the most successful sire in American racing history The early days of American horse racing were grueling. Four-mile races, run two or three times in succession, were the norm, rewarding horses who brandished the ideal combination of stamina and speed. The stallion Lexington, named after the city in Kentucky where he was born, possessed these ...
Ellen Emmet Rand (1875-1941) was one of the most important and prolific portraitists in the United States in the first decades of the twentieth century. She negotiated her career, reputation, family, and finances in modern and commercially savvy ways-revealing the complex negotiations needed to balance these competing pressures. Engaging with newly available archival documents and featuring scholars with radically different approaches to visual culture, this edited collection not only seeks to interrogate the meaning of Rand's portraits and her career, but indeed to rethink gender, art, race, business, and modernism in the twentieth century.
Explores the ongoing transformation of service relationships, focusing on the incorporation of the customer's active contribution to virtually all aspects and stages of the production process. This volume illuminates social relations and interaction between customers and service providers as well as between the users of web-based services.
Entwicklungen in der Arbeitswelt, die unter den Stichworten "Arbeit 4.0" und "Industrie 4.0" diskutiert werden, beziehen sich im Wesentlichen auf die Technologisierung und Digitalisierung von Arbeitsplätzen. Neu ist die Vernetzung der verschiedensten Fertigungs- und Produktionsprozesse, verbunden mit einer Neugestaltung der Produktentwicklung. Wesentliche Elemente sind die Selbststeuerung und Kontrolle der Komponentenfertigung zur individualisierten bzw. personalisierten Produktgestaltung. Durch die Digitalisierung werden ökomische Prozesse beschleunigt und die internationale Vernetzung der Wirtschaft erhält einen wesentlich höheren Stellenwert. Noch wird zu wenig gefragt, welche Auswirk...