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Advances in Diffusion Magnetic Resonance Imaging with Application to Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic neurodegenerative disease which is mainly characterized by inflammation, demyelination, and axonal loss. Conventional Magnetic Resonance Imaging (MRI) has become the most established imaging tool in the diagnosis and follow-up of MS in clinical practice. However, the high sensitivity of these standard MRI techniques is mainly restricted to the detection of focal demyelinating MS lesions, mainly in white matter (WM), as they fail to depict further damage in normal appearing WM (NAWM) and grey matter (GM) involvement. More advanced quantitative MRI methods, including diffusion MRI, have been applied in MS research and they have improved the detection and in...
Diana Valdés
None
Diffusion-Weighted MR Imaging (DW-MRI) and Diffusion-Weighted MR Spectroscopy (DW-MRS)
Magnetic Resonance Imaging (MRI) is a unique technique that provides tissue-specific contrast non-invasively. However, even at ultra-high field, resolution remains on the millimeter scale, far above cellular microstructure. Taking the fact that diffusion of nuclear spins in magnetic field gradients results in a characteristic signal loss, MRI can be sensitized to water-diffusion (DW-MRI) to recover microstructural information indirectly. Diffusion-Weighted MR Spectroscopy (DW-MRS) goes one step further by not measuring the diffusion of tissue water but of cell-type specific metabolites. Given that, both techniques can provide complementary information: DW-MRI on water diffusion with high spa...
Atlas of Human Brain Connections
One of the major challenges of modern neuroscience is to define the complex pattern of neural connections that underlie cognition and behaviour. This atlas capitalises on novel diffusion MRI tractography methods to provide a comprehensive overview of connections derived from virtual in vivo tractography dissections of the human brain.
Recent Advances in Electrical Engineering, Electronics and Energy
This book constitutes the proceedings of the XV Multidisciplinary International Congress on Science and Technology (CIT 2020), held in Quito, Ecuador, on 26–30 October 2020, proudly organized by Universidad de las Fuerzas Armadas ESPE in collaboration with GDEON. CIT is an international event with a multidisciplinary approach that promotes the dissemination of advances in Science and Technology research through the presentation of keynote conferences. In CIT, theoretical, technical, or application works that are research products are presented to discuss and debate ideas, experiences, and challenges. Presenting high-quality, peer-reviewed papers, the book discusses the following topics: • Electrical and Electronic• Energy and Mechanics
The Archive and the Repertoire
In The Archive and the Repertoire preeminent performance studies scholar Diana Taylor provides a new understanding of the vital role of performance in the Americas. From plays to official events to grassroots protests, performance, she argues, must be taken seriously as a means of storing and transmitting knowledge. Taylor reveals how the repertoire of embodied memory—conveyed in gestures, the spoken word, movement, dance, song, and other performances—offers alternative perspectives to those derived from the written archive and is particularly useful to a reconsideration of historical processes of transnational contact. The Archive and the Repertoire invites a remapping of the Americas b...
Self Portrait in Green
'NDiaye is a hypnotic storyteller with an unflinching understanding of the rock-bottom reality of most people's life.' New York Times ' One of France's most exciting prose stylists.' The Guardian. Obsessed by her encounters with the mysterious green women, and haunted by the Garonne River, a nameless narrator seeks them out in La Roele, Paris, Marseille, and Ouagadougou. Each encounter reveals different aspects of the women; real or imagined, dead or alive, seductive or suicidal, driving the narrator deeper into her obsession, in this unsettling exploration of identity, memory and paranoia. Self Portrait in Green is the multi-prize winning, Marie NDiaye's brilliant subversion of the memoir. Written in diary entries, with lyrical prose and dreamlike imagery, we start with and return to the river, which mirrors the narrative by posing more questions than it answers.
Assessment of Vulnerability to Natural Hazards
Assessment of Vulnerability to Natural Hazards covers the vulnerability of human and environmental systems to climate change and eight natural hazards: earthquakes, floods, landslides, avalanches, forest fires, drought, coastal erosion, and heat waves. This book is an important contribution to the field, clarifying terms and investigating the nature of vulnerability to hazards in general and in various specific European contexts. In addition, this book helps improve understanding of vulnerability and gives thorough methodologies for investigating situations in which people and their environments are vulnerable to hazards. With case studies taken from across Europe, the underlying theoretical...
Human Rights and Transnational Solidarity in Cold War Latin America
With the end of the global Cold War, the struggle for human rights has emerged as one of the most controversial forces of change in Latin America. Many observers seek the foundations of that movement in notions of rights and models of democratic institutions that originated in the global North. Challenging that view, this volume argues that Latin American community organizers, intellectuals, novelists, priests, students, artists, urban pobladores, refugees, migrants, and common people have contributed significantly to new visions of political community and participatory democracy. These local actors built an alternative transnational solidarity from below with significant participation of the socially excluded and activists in the global South. Edited by Jessica Stites Mor, this book offers fine-grained case studies that show how Latin America’s re-emerging Left transformed the struggles against dictatorship and repression of the Cold War into the language of anti-colonialism, socioeconomic rights, and identity.
Evolution of Translational Omics
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
