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Establecer hipótesis, consultar con diversas fuentes directas e indirectas, contrastar la información, validarla o rechazarla, llegar a conclusiones y mostrarlas o diseminarlas son algunas de las etapas del método científico aplicable aquí. Las estrategias didácticas que facilitan el trabajo en cada uno de estos pasos conforman los procedimientos típicos de las ciencias sociales. El lector que se acerque a este libro encontrará buenas prácticas de otros profesionales, tanto de infantil y primaria como de secundaria, así como la reflexión sobre algunas de las estrategias y también su fundamentación teórica.
This book is based on the best contributions to the advancement of bioimpedance knowledge and use from the Latin American Congress series, CLABIO. Basic bioimpedance facts as well as promising and original contributions to bioimpedance theory and applications are presented, giving the reader stimulating material for reflection, decision making, and further experiments. Contributions come from a diverse international pool of experts and address topics on electrode and skin impedance modelling, tomography, spectroscopy, instrumentation, and clinical applications.
This book explains the fundamental concepts and theoretical techniques used to understand the properties of quantum systems having large numbers of degrees of freedom. A number of complimentary approaches are developed, including perturbation theory; nonperturbative approximations based on functional integrals; general arguments based on order parameters, symmetry, and Fermi liquid theory; and stochastic methods.
This text presents the statistical theory of wave scattering and quantum transport in complex - chaotic and disordered - systems.
This volume is an introductory level textbook for partial differential equations (PDE's) and suitable for a one-semester undergraduate level or two-semester graduate level course in PDE's or applied mathematics. Chapters One to Five are organized according to the equations and the basic PDE's are introduced in an easy to understand manner. They include the first-order equations and the three fundamental second-order equations, i.e. the heat, wave and Laplace equations. Through these equations we learn the types of problems, how we pose the problems, and the methods of solutions such as the separation of variables and the method of characteristics. The modeling aspects are explained as well. The methods introduced in earlier chapters are developed further in Chapters Six to Twelve. They include the Fourier series, the Fourier and the Laplace transforms, and the Green's functions. The equations in higher dimensions are also discussed in detail.This volume is application-oriented and rich in examples. Going through these examples, the reader is able to easily grasp the basics of PDE's.
Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
Nanomachines represent one of the most fascinating topics in of nanotechnology. These tiny devices provide diverse opportunities towards a wide range of important applications, ranging from targeted delivery of drug payloads to environmental remediation. This book addresses comprehensively the latest developments and discoveries in the field of nano- and microscale machines. It covers the evolution of nanomachines in general from a historical perspective, the fundamental challenges for motion at the nanoscale, different categories of biological and synthetic nano/microscale motors based on different propulsion mechanisms, ways for controlling the movement directionality and regulated speed, ...
Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.
Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leadin...