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Recursos y estrategias para estudiar ciencias sociales
Establecer hipótesis, consultar con diversas fuentes directas e indirectas, contrastar la información, validarla o rechazarla, llegar a conclusiones y mostrarlas o diseminarlas son algunas de las etapas del método científico aplicable aquí. Las estrategias didácticas que facilitan el trabajo en cada uno de estos pasos conforman los procedimientos típicos de las ciencias sociales. El lector que se acerque a este libro encontrará buenas prácticas de otros profesionales, tanto de infantil y primaria como de secundaria, así como la reflexión sobre algunas de las estrategias y también su fundamentación teórica.
Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design
This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic ...
Cognitive Impairment in Schizophrenia
Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.
Nanomachines
Nanomachines represent one of the most fascinating topics in of nanotechnology. These tiny devices provide diverse opportunities towards a wide range of important applications, ranging from targeted delivery of drug payloads to environmental remediation. This book addresses comprehensively the latest developments and discoveries in the field of nano- and microscale machines. It covers the evolution of nanomachines in general from a historical perspective, the fundamental challenges for motion at the nanoscale, different categories of biological and synthetic nano/microscale motors based on different propulsion mechanisms, ways for controlling the movement directionality and regulated speed, ...
Treatment–Refractory Schizophrenia
Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leadin...
Structure-Based Drug Design
Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
Outline
The first in Rachel Cusk's landmark trilogy, shortlisted for the Folio Prize and the Goldsmith Prize and longlisted for the IMPAC Prize. 'A work of stunning beauty, deep insight and great originality.' Monica Ali, New York Times 'One of the most daringly original and entertaining pieces of fiction I've ever read.' Observer 'A perfect synthesis of form and content.' Deborah Levy Outline is a novel in ten conversations. Spare and lucid, it follows a novelist teaching a course in creative writing over an oppressively hot summer in Athens. She leads her student in storytelling exercises. She meets other writers for dinner. She goes swimming in the Ionian Sea with her seatmate from the place. The people she encounters speak volubly about themselves, their fantasies, anxieties, pet theories, regrets, and longings. And through these disclosures, a portrait of the narrator is drawn by contrast, a portrait of a woman learning to face great a great loss.
The Cultural Legacy of María Zambrano
The philosopher María Zambrano (1904-1991) is one of the foremost Spanish intellectuals of the twentieth century. A disciple of Ortega y Gasset, she taught at the University of Madrid in the 1930s and joined the Republican diaspora in exile, living in México, Cuba, Puerto Rico, Paris, Rome and Geneva till her return to Spain in 1984. A heterodox philosopher who conceived her role as that of an agent for ethical change, she sought to reconcile philosophy and poetry, and wrote not only essays on philosophy, but also plays, poetry, literary and art reviews, and a memoir. After the relative obscurity of her life in exile, her genius began to be recognized in the decade before her death, but she remains little known outside the Spanish-speaking world. These essays explore her legacy, offering new critical insights which draw on literature, aesthetics, gender studies, psychoanalysis, political theory and the visual arts. The editors teach modern Spanish literature at the University of Oxford, where Xon de Ros is a Tutorial Fellow at Lady Margaret Hall and Somerville College, and Daniela Omlor is a Tutorial Fellow at Lincoln College and a Lecturer at Jesus College.
