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Retinoic acid-related orphan receptors regulate autophagy and cell survival in cardiac myocytes during hypoxic stress
Introduction: Autophagy is a highly conserved evolutionary process that regulates cell quality control through protein degradation, organelle turnover, and recycling of cellular components by fusing with lysosomes. Defects in autophagy can lead to increased reactive oxygen species (ROS) and oxidative stress from impaired mitochondrial clearance by mitophagy. These defects are commonly associated with chronic human diseases such as cancer, myocardial infarction, neurodegenerative diseases, and aging. Aim: Herein, we show that the gene Retinoic Acid-Related Orphan Receptors α (Rora) is cardioprotective through modulation of autophagy and clearance of damaged ROS-producing mitochondria in card...
Biochemistry of Cardiovascular Dysfunction in Obesity
Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiova...
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Einstein's Telescope: The Hunt for Dark Matter and Dark Energy in the Universe
"In Einstein’s Telescope, Evalyn Gates, an expert on all that’s dark in the universe, brings dark matter, dark energy, and even black holes to light." —Neil deGrasse Tyson, astrophysicist, American Museum of Natural History, and New York Times best-selling author of Astrophysics for People in a Hurry In 1936, Albert Einstein predicted that gravitational distortions would allow space itself to act as a telescope far more powerful than humans could ever build. Now, cosmologists at the forefront of their field are using this radical technique ("Einstein’s Telescope") to detect the invisible. In fresh, engaging prose, astrophysicist Evalyn Gates explains how this tool is enabling scientists to uncover planets as big as the Earth, discover black holes as they whirl through space, and trace the evolution of cosmic architecture over billions of years. Powerful and accessible, Einstein’s Telescope takes us to the brink of a revolution in our understanding of the deepest mysteries of the Universe.
O Say Can You See...
A collection of 8 patriotic photos -- most of them include pre-school age children and the flag -- accompany the text of the Star Spangle Banner.
Those who Hold Bastogne
A new telling of the brutal siege of Bastogne, where vastly outnumbered American forces held off a savage German onslaught and sealed the fate of the Third Reich Hitler's last gamble, the Battle of the Bulge, was intended to push the Allied invaders of Normandy all the way back to the beaches. The plan nearly succeeded, and almost certainly would have, were it not for one small Belgian town and its tenacious American defenders who held back a tenfold larger German force while awaiting the arrival of General George Patton's mighty Third Army. In this dramatic account of the 1944-45 winter of war in Bastogne, historian Peter Schrijvers offers the first full story of the German assault on the s...
Good Germs, Bad Germs
Making Peace with Microbes Public sanitation and antibiotic drugs have brought about historic increases in the human life span; they have also unintentionally produced new health crises by disrupting the intimate, age-old balance between humans and the microorganisms that inhabit our bodies and our environment. As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"— an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes—which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones—each custom-designed for maximum health benefits.
Reinventing the University
This book offers a radically new vision of how the university might become a special sort of workplace/community of thinkers and doers, working together to understand and solve real human problems, in a competitive global market. It is a practical vision created by experienced authors. Can the finest minds, traditionally associated with universities, devote themselves to the long-term interests of the planet and our descendants? What would happen if they could join together, worldwide, to find solutions to complex human problems? What will happen to the university and to us if they do not?
The American Jury On Trial
First Published in 1988. More than 3 million Americans are called for jury duty every year. For most people, serving on a jury arouses two feelings: it is both a personal sacrifice and an exciting experience. And where a jury is asked to decide some cases, they make headlines. As a result of trials such as these, the American system of trial by jury faces unprecedented challenges. This volume offers an informed examination of the entire process, from jury selection to the delivery of a verdict. Quoting the experiences and expertise of F. Lee Bailey, William Kunstler, Clarence Darrow, Learned Hand, and many others, ttis book investigates such important factors as pretrial bias, the psychology of evidence, inadmissible testimony, interpreting the law, and what goes on inside the jury room. People often think that any book dealing with the law must be written in ‘legalese’ but in in this book, Professors Kassin and Wrightsman present their case in an exceptionally readable style. They utilize modern advances in psychology to illuminate the usually hidden world of trial practice and procedure and offer thoughtful possibilities for improving the system.
The Italian Risorgimento
The Risorgimento was a turbulent and decisive period in the history of Italy. Lucy Riall's engaging account is the first book of its kind on the upheavals of the years between 1815 and 1860, when a series of crises destabilised the states of Restoration Italy and led to the creation of a troubled nation state in 1860. Comprehensive, yet original, this textbook: * Examines the social history of nineteenth century Italy and the social context of political action * Offers a critical overview of the historiography of the topic * Takes account of the most recent literature, especially literature in Italian not normally accessible to students * Adopts a broad thematic approach * Places the Italian experience in a European context
