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Patient-derived Xenograft Mouse Models to Investigate Tropism to the Central Nervous System and Retina of Primary and Secondary Central Nervous System Lymphoma
Abstract: Aims How and why lymphoma cells home to the central nervous system and vitreoretinal compartment in primary diffuse large B-cell lymphoma of the central nervous system remain unknown. Our aim was to create an in vivo model to study lymphoma cell tropism to the central nervous system. Methods We established a patient-derived central nervous system lymphoma xenograft mouse model and characterised xenografts derived from four primary and four secondary central nervous system lymphoma patients using immunohistochemistry, flow cytometry and nucleic acid sequencing technology. In reimplantation experiments, we analysed dissemination patterns of orthotopic and heterotopic xenografts and p...
Worldlines: A "Many Worlds" Novel
When Gary Jackson, a bright academic student, suffers life changing injuries in a road traffic accident, his world begins to unravel. Having taught himself to lucid dream, he now spends considerable time in bed, living out fantasies in his own mind that he could never experience in the waking world. However, when a relative with dementia claims to have witnessed a murder he committed in a dream, Gary starts to question the nature of reality, and wonders if his actions in the dream world have real life consequences. Meanwhile, in another place, Physics student Gary Jackson finds himself in prison for a murder he has no memory of committing. Can the dreamer help the student get acquitted for a murder everyone saw him commit? Or will Gary spend his life in prison for someone else's crime?
Quantitative MRI of the Spinal Cord
Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply t...
Small Remedies
Shashi Deshpande's latest novel explores the lives of two women, one obsessed with music and the other a passionate believer in Communism, who break away from their families to seek fulfilment in public life. Savitribai Indorekar, born into an orthodox Hindu family, elopes with her Muslim lover and accompanist, Ghulaam Saab, to pursue a career in music. Gentle, strong-willed Leela, on the other hand, gives her life to the Party, and to working with the factory workers of Bombay. Fifty years after these events have been set in motion, Madhu, Leela's niece, travels to Bhavanipur, Savitribai's home in her last years, to write a biography of Bai. Caught in her own despair over the loss of her only son. Madhu tries to make sense of the lives of Bai and those around her, and in doing so, seeks to find a way out of her own grief.
Viral Applications of Green Fluorescent Protein
Over the last ten years, Green Fluorescent Proteins, along with the other spectral variants, have emerged from near obscurity to become a powerful and versatile tool in scientific research. In Viral Applications of Green Fluorescent Protein: Methods and Protocols, leading investigators from around the world contribute detailed examples of both the construction and application of fluorescent proteins delivered by viruses in a format crafted to produce rapid, readily reproducible results. Written in the style of the popular and successful Methods in Molecular BiologyTM series, the chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, Viral Applications of Green Fluorescent Protein: Methods and Protocols supplies researchers with an ideal guide to the many uses of GFP and a vital starting point for future studies utilizing this highly adaptable protein.
NGF and Related Molecules in Health and Disease
The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins pla...
The Shore 2
Buy this notebook with totally new design, it is about the shore in a beautiful and brilliants colors to write your thoughts, or what you still have to do, from simple notes to long texts; It can be used while we are on the train, on the bus, classroom or just walking around on the beach, watching tv and enjoying the afternoon. It is ideal for any time of day that we have time to write. It is a beautiful gift for any surfer, a student, beach lovers, ocean lovers or any one of your friends or family, who will surely appreciate it. It is a diary made with love for those who love the writing, the beach and surf. Made with love to spread love everywhere.
