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An important study on the making of molecular biology and its cultural contexts.
John C. Kendrew (1917-1997) was a pioneer in structural biology and a catalyst for the emergence of molecular biology in the second half of the twentieth century. He was the first person to determine the three-dimensional structure of a protein at atomic resolution and, for this, was awarded the Nobel Prize in Chemistry in 1962. Kendrew ultimately became an international organizer, administrator, and advocate for science, and his expansive legacy lives on today. In this book, Paul M. Wassarman, a postdoctoral fellow with Kendrew in the late 1960s, delves into Kendrew's personal and scientific life to uncover the background, traits, and experiences of the man responsible for so many achieveme...
Born by mistake, or connivance, to struggling parents in a small Lancashire cotton town in 1903, an uninspired Darlington inadvertently escaped the obscurity of farming life and rose instead, against all odds, to become within a few short years the world's greatest expert on chromosomes, and one of the most penetrating biological thinkers of the twentieth century. Harman follows Darlington's path from bleak prospects to world fame, showing how, within the most miniscule of worlds, he sought answers to the biggest questions--how species originate, how variation occurs, how Nature, both blind and foreboding, random and insightful, makes her way from deep past to unknown future. But Darlington ...
A Stanford University Press classic.
A Jew who left Germany when Hitler came to power, Sir Ernst Chain was a winner, with Sir Alexander Fleming and Lord Florey, of the Nobel Prize for Physiology and Medicine in 1945. Later he was a significant figure in the use of the semi-synthetic penicillins which, from the mid-1950s onwards, revolutionized the use of the antiĀbiotic in more than one field of medicine. Born in Berlin in 1906, of a Russian emigre father and a German mother, Chain left Germany for England on 30 January 1933. Working first with Sir Frederick Gowland Hopkins in Cambridge, then with Professor Howard Florey in Oxford, Chain studied the biochemical processes by which bacteriolytic agents operate. Writing up his results, he studied Fleming's neglected original report of the bacteria-inhibiting properties of penicillin, and with Florey's support embarked on a major investigation of how penicillin could be made and purified.