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Principles and Practice of Clinical Trials
This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this po...
Rare Genetic Variants Affecting Urine Metabolite Levels Link Population Variation to Inborn Errors of Metabolism
Abstract: Metabolite levels in urine may provide insights into genetic mechanisms shaping their related pathways. We therefore investigate the cumulative contribution of rare, exonic genetic variants on urine levels of 1487 metabolites and 53,714 metabolite ratios among 4864 GCKD study participants. Here we report the detection of 128 significant associations involving 30 unique genes, 16 of which are known to underlie inborn errors of metabolism. The 30 genes are strongly enriched for shared expression in liver and kidney (odds ratio = 65, p-FDR = 3e−7), with hepatocytes and proximal tubule cells as driving cell types. Use of UK Biobank whole-exome sequencing data links genes to diseases connected to the identified metabolites. In silico constraint-based modeling of gene knockouts in a virtual whole-body, organ-resolved metabolic human correctly predicts the observed direction of metabolite changes, highlighting the potential of linking population genetics to modeling. Our study implicates candidate variants and genes for inborn errors of metabolism
Towards Inclusion of All Learners through Science Teacher Education
Towards Inclusion of All Learners through Science Teacher Education serves as an indispensable resource for teachers and teacher educators wishing to understand how to educate students with exceptionalities in science. This book begins with the voices and stories of the experts: current and former K-12 students with disabilities sharing their experiences in science education classrooms. The voices of students with disabilities are then connected to the work of leading experts in the area of science education for individuals with disabilities in an effort to address the goals of national reform documents by ensuring rigorous science experiences for all students. It is written in a highly accessible and practical manner, making it ideal for all educators including pre-service and in-service teachers, teacher educators, researchers, and curriculum developers.
In the Twilight of Empire. Count Alois Lexa von Aehrenthal (1854–1912)
Count Alois Lexa von Aehrenthal (1854-1912) was the most important Austro-Hungarian diplomat in the period before the First World War. Volume Two of Solomon Wank's brilliant biography covers Aehrenthal's years as foreign minister from 1906 until his death in 1912. This includes the dramatic events of the Bosnian annexation crisis in 1908/09 when Aehrenthal brought Europe to the brink of war until he retreated from the precipice once he recognized the abyss.
The Politics and Rhetoric of Collective Remembering
This book critically examines the ways that collective pasts are commemorated and contested in a wide variety of national locations, media and genres. Collective remembering is a dynamic process, through which narratives about the past, about ‘us’ and ‘them’ as well as beliefs, values and affective conditions contained in these stories, are produced and reproduced. This facilitates room for not only the creation of unity but also the potential for contestation and conflict, given that different interpretations of the past are often vehicles for opposing political interests. This book reflects the geographical breadth and empirical depth of the field of collective remembering. Foregro...
