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Alzheimer's Disease
Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.
Computational Approaches for Identifying Drugs Against Alzheimer's Disease
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function o...
Living with Alzheimer's
News of Alzheimer’s disease is constantly in the headlines. Every day we hear heart-wrenching stories of people caring for a loved one who has become a shell of their former self, of projections about rising incidence rates, and of cures that are just around the corner. However, we don't see or hear from the people who actually have the disease. In Living with Alzheimer’s, Renée L. Beard argues that the exclusively negative portrayals of Alzheimer’s are grossly inaccurate. To understand what life with memory loss is really like, Beard draws on intensive observations of nearly 100 seniors undergoing cognitive evaluation, as well as post-diagnosis interviews with individuals experiencin...
Promoting Active Citizenship
This book is open access under a CC BY 4.0 license. This book analyses the considerable variation in the shares of private provision for core services in education, health and social services, in the Scandinavian countries. The chapters compare countries, service areas, and the for-profit, non-profit and public sectors. Each focuses on different levels of change: the mix of welfare providers, national laws and regulations, governance in municipalities, nursing homes and schools, and finally, the consequences experienced by the users of the services. The authors ask which combinations of governance structures, service sector providers, and user choice give the best results for active citizenship. Promoting Active Citizenship will be of interest to students and scholars across a range of disciplines, including Public Administration and Management, Non-Profit Management, Social Policy, Innovation in Public Service, Social Care and Education and School Research.
Mood and Cognition in Old Age
Improving psychological well-being and cognitive health is now listed as the priority on the healthy aging agenda. Depression and cognitive impairment are great challenges for the elderly population. There have been numerous studies on depression and cognitive impairment and dementia. However, the neural correlates of depression and cognitive impairment have not yet been elucidated. With the development of neuroscience and relevant technologies, studies on anatomical and functional neural networks, neurobiological mechanisms of mood and cognition in old age will provide more insight into the potential diagnosis, prevention and intervention in depression and cognitive impairment. For example,...
Early Psychosocial Interventions in Dementia
For the increasing number of people diagnosed with dementia each year, treatment in the early stages can make a significant difference to their quality of life. This book provides examples of psychosocial interventions: taking into consideration the individual, social and environmental aspects of the person's life. It looks at ways of providing support at the time of diagnosis and goes on to explore a variety of interventions and services for the treatment of early dementia. Bringing together the knowledge and experiences of professionals from both the UK and Europe, the contributors describe interventions for both psychological and practical problems with case examples such as memory support groups, art therapies and assistive technologies for use in the home. This accessible book will be essential reading for practitioners and carers working with those with early dementia and will be extremely useful in both professional development and for those new to dementia care.
Understanding Clinical Papers
For two decades, Understanding Clinical Papers has been helping students and professionals understand the research that supports evidence-based practice. Now in its fourth edition, this popular introductory textbook covers every major aspect of reading and evaluating clinical research literature, from identifying the aims and objectives of a paper to analysing the data with different multivariable methods. Numerous excerpts from actual clinical research papers make learning real and immediate, supported by a unique visual approach that reinforces key points and connects examples with the chapter material. The fourth edition includes extensively revised content throughout, including four bran...
Human Development Report 1996
The Human Development Report, now in its seventh edition, updates the unique Human Development Indicators comparing human development in most countries of the world, and the data tables on all aspects of human development. The special focus of this edition is on the important link between economic growth and human development. The Report maintains that the link is not automatic but can be established through proper policy management, arguing the case for initiating and accelerating economic growth and at the same time accelerating and sustaining human development in different parts of the world. The Report also maintains that the quality of growth is as important as its quantity; otherwise, ...
Competence Assessment in Dementia
The increasing proportion of demented elderly in populations, debates over patient’s rights and autonomy, and the growing body of knowledge on dementia has inspired the European Dementia Consensus Network to regard competence assessment in dementia as an important topic of debate. This book contains a summarised consensus as well as chapters on state-of-art neuropsychological functions and how they relate to competence, and chapters discussing ethical, legal perspectives.
