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Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
Computer Supported Qualitative Research
This book includes selecting the articles accepted for presentation and discussion at WCQR2021, held on January 20th to 22nd, 2021 (Virtual Conference). The World Conference on Qualitative Research (WCQR) is an annual event that aims to bring together researchers, academics and professionals, promoting the sharing and discussion of knowledge, new perspectives, experiences and innovations on Qualitative Research. WCQR2021 featured four main application fields (Education, Health, Social Sciences, and Engineering/Technology) and seven main subjects: Rationale and Paradigms of Qualitative Research; Systematization of Approaches with Qualitative Studies; Qualitative and Mixed Methods Research; Data Analysis Types; Innovative Processes of Qualitative Data Analysis; Qualitative Research in Web Context; Qualitative Analysis with Software Support. The book is a valuable resource for everyone interested in qualitative research, emphasizing Computer-Assisted Qualitative Data Analysis Software (CAQDAS).
WJP Rule of Law Index 2016
The World Justice Project (WJP) joins efforts to produce reliable data on rule of law through the WJP Rule of Law Index 2016, the sixth report in an annual series, which measures rule of law based on the experiences and perceptions of the general public and in-country experts worldwide. We hope this annual publication, anchored in actual experiences, will help identify strengths and weaknesses in each country under review and encourage policy choices that strengthen the rule of law. The WJP Rule of Law Index 2016 presents a portrait of the rule of law in each country by providing scores and rankings organized around eights factors: constraints on government powers, absence of corruption, ope...
VIOLÊNCIAS
Este livro é o 14o. publicado pelo NEVIRG (Núcleo de Estudos "Violência e Relações de Gênero") – CNPq e trata-se de uma coletânea de textos sobre pesquisas bibliográficas, de revisão e de campo, além de ensaios e relatos de experiências. A Parte I aborda as violências nas diferentes formas de expressão, como a política (08 /01/2023); os desafios da covid-19 para a vigilância das violências das cidades; e a eficácia social e a responsabilização criminal do agressor pela Lei Maria da Penha. A Parte II traz uma atualização do movimento feminista da região Norte do Brasil, especialmente do Estado do Pará e do Amazonas, por meio de falas de profissionais da área em questão.
Carmen Abroad
A transnational history of the performance, reception, translation, adaptation and appropriation of Bizet's Carmen from 1875 to 1945. This volume explores how Bizet's opera swiftly travelled the globe, and how the story, the music, the staging and the singers appealed to audiences in diverse contexts.
Catalog of Living Whales
This catalog was originally designed as a checklist of the cetaceans of South American waters only. It was clear from the start, however, that comparable limitations could not be imposed on the range of the literature to be consulted. With nearly all the essential literature at hand, it was decided to include the extraterritorial forms and make a catalog worldwide in scope.
Psicologia Social e Política de Assistência Social: Territórios, Sujeitos e Inquietações
A obra Psicologia social e política de assistência social: territórios, sujeitos e inquietações é uma coletânea nacional, com a participação de pesquisadoras e pesquisadores de várias Universidades brasileiras. O conceito de território é investigado, mapeado e toma como parâmetro a centralidade que assume na Política Nacional de Assistência Social (PNAS) e no Sistema Único de Assistência Social (Suas), bem como a produção de sujeitos por meio das normatizações e normalizações no campo da Assistência Social. Além disso, o livro traça reflexões e inquietações sobre os desafios da acolhida da Psicologia em práticas cotidianas nos espaços socioassistenciais, o orde...
Psicologia: Olhares Temáticos
A construção do estado da arte em qualquer campo epistêmico passa por diferentes trajetórias institucionais teórico-metodológicas e de poder, as quais demonstram a importância de se apreender o que é produzido, como se produz e quem produz, razão pela qual este livro oportuniza uma coletiva contribuição ao pensamento da Psicologia a partir das macrorregiões Norte de Centro-Oeste do Brasil. Neste contexto, o objetivo da presente obra é apresentar uma visão panorâmica sobre o campo epistêmico (científico e profissional) da Psicologia, por meio de uma agenda de estudos que focaliza a riqueza de experiências empíricas e de conhecimentos existentes nas macrorregiões Norte e Ce...
XXVII Brazilian Congress on Biomedical Engineering
This book presents cutting-edge research and developments in the field of Biomedical Engineering. It describes both fundamental and clinically-oriented findings, highlighting advantages and challenges of innovative methods and technologies, such as artificial intelligence, wearable devices and neuroengineering, important issues related to health technology management and human factors in health, and new findings in biomechanical analysis and modeling. Gathering the proceedings of the XXVII Brazilian Congress on Biomedical Engineering, CBEB 2020, held on October 26-30, 2020, in Vitória, Brazil, and promoted by the Brazilian Society of Biomedical Engineering – SBEB, this book gives emphasis to research and developments carried out by Brazilian scientists, institutions and professionals. It offers an extensive overview on new trends and clinical implementation of technologies, and it is intended to foster communication and collaboration between medical scientists, engineers, and researchers inside and outside the country.
Cardiovascular Surgery
This clinical casebook is comprised of surgical cases involving the most important cardiovascular diseases in a concise, easy-to-read format (5x8 in trim size, like other titles in this burgeoning, informal product line in the Springer clinical medicine program). Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as questions and answers (between 8 and 10) about relevant aspects related to the diagnosis and treatment of the addressed disease. The Q&A section will broaden discussion and increase the title's pedagogical value. The casebook features 40 surgical cases in...
