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Resistance to Molecular Therapies for Hepatocellular Carcinoma
This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
Handbook of Mitochondrial Dysfunction
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
Sensor Technology: Concepts, Methodologies, Tools, and Applications
Collecting and processing data is a necessary aspect of living in a technologically advanced society. Whether it’s monitoring events, controlling different variables, or using decision-making applications, it is important to have a system that is both inexpensive and capable of coping with high amounts of data. As the application of these networks becomes more common, it becomes imperative to evaluate their effectiveness as well as other opportunities for possible implementation in the future. Sensor Technology: Concepts, Methodologies, Tools, and Applications is a vital reference source that brings together new ways to process and monitor data and to put it to work in everything from intelligent transportation systems to healthcare to multimedia applications. It also provides inclusive coverage on the processing and applications of wireless communication, sensor networks, and mobile computing. Highlighting a range of topics such as internet of things, signal processing hardware, and wireless sensor technologies, this multi-volume book is ideally designed for research and development engineers, IT specialists, developers, graduate students, academics, and researchers.
Freedom through Submission: Muslim-talk in Contemporary Denmark
In Freedom through Submission Johannes Renders explores Danish-Muslim statements on human freedom, analysing the Muslim community’s attempts to reconfigure a public debate that pits freedom against islam.
Characterization of Minerals, Metals, and Materials 2020
This collection gives broad and up-to-date results in the research and development of materials characterization and processing. Topics covered include advanced characterization methods, minerals, mechanical properties, coatings, polymers and composites, corrosion, welding, magnetic materials, and electronic materials. The book explores scientific processes to characterize materials using modern technologies, and focuses on the interrelationships and interdependence among processing, structure, properties, and performance of materials.
A Master Regulator of Oxidative StressThe Transcription Factor Nrf2
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
Proceedings of the 6th Brazilian Technology Symposium (BTSym’20)
This book presents the Proceedings of The 6th Brazilian Technology Symposium (BTSym'20). The book discusses the current technological issues on Systems Engineering, Mathematics and Physical Sciences, such as the Transmission Line, Protein-Modified Mortars, Electromagnetic Properties, Clock Domains, Chebyshev Polynomials, Satellite Control Systems, Hough Transform, Watershed Transform, Blood Smear Images, Toxoplasma Gondi, Operation System Developments, MIMO Systems, Geothermal-Photovoltaic Energy Systems, Mineral Flotation Application, CMOS Techniques, Frameworks Developments, Physiological Parameters Applications, Brain–Computer Interface, Artificial Neural Networks, Computational Vision,...
The Country of Others
'A panoramic, ambitious tale.' The Times'Exceptional.' Salman Rushdie'Powerful.' Christine Mangan'Captivating.' Elle1944. After the Liberation, Mathilde leaves France to join her husband in Morocco.But life here is unrecognisable to this brave and passionate young woman. Her life is now that of a farmer's wife - with all the sacrifices and vexations that brings. Suffocated by the heat, by her loneliness on the farm and by the mistrust she inspires as a foreigner, Mathilde grows increasingly restless.As Morocco's struggle for independence intensifies, Mathilde and her husband find themselves caught in the crossfire.From the internationally bestselling author, The Country of Others is perfect for fans of Elena Ferrante, Tracy Chevalier, and Maggie O'Farrell.
