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Tumor-Associated Fibroblasts and their Matrix
During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on “Tumor-associated fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment” is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.
The Cancer Degradome
This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.
Tumor Angiogenesis
Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.
Advances in Micro-Bioreactor Design for Organ Cell Studies
This book is a printed edition of the Special Issue "Advances in Micro-Bioreactor Design for Organ Cell Studies" that was published in Bioengineering
Social Dynamics of the Life Course
In the last two decades, research on the life course has successfully combined and integrated different and rather isolated fields of social concerns such as: the labor market, family solidarity, education, employment, retirement, and social policy. It has also developed a special focus on crucial problems of sociological research, which includes the understanding of micromacro phenomena, the dynamics of social change, and international comparisons. Contributors to this volume take an international, comparative approach in applying the life course theoretical framework to issues of work and career. Life course research focuses on the relationship between institutions and individuals across t...
The Journey Before Us
More students are enrolling in college than ever before in U.S. history. Yet, many never graduate. In The Journey Before Us, Laura Nichols examines why this is by sharing the experiences of aspiring first-generation college students as they move from middle-school to young adulthood. By following the educational trajectories and transitions of Latinx, mainly second-generation immigrant students and analyzing national data, Nichols explores the different paths that students take and the factors that make a difference. The interconnected role of schools, neighborhoods, policy, employment, advocates, identity, social class, and family reveal what must change to address the “college completion crisis.” Appropriate for anyone wanting to understand their own educational journey as well as students, teachers, counselors, school administrators, scholars, and policymakers, The Journey Before Us outlines what is needed so that education can once again be a means of social mobility for those who would be the first in their families to graduate from college.
Life Course, Work, and Labour in Global History
This multidisciplinary volume offers unique perspectives, across the globe and throughout the centuries, on the complexity of the nexus between work and the life course. For industrialized regions, from Germany and Western Europe to China and Japan, it questions the widespread notion of an overall growing working life course instability, since the 1970s. For unindustrialized or industrializing regions, from West Africa to state socialist East Central Europe, as well as for transnational and transcontinental labour migrations, it shows the enormous influence of the extended family and wider kin on individual pathways into and out of work. For early modern Europe, India, and China, and up to t...
