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Application of Fishes as Biological Models in Genetic Studies
Although Gregor Mendel is considered the father of genetics, he has never taken the credit for his principles on heredity. Mendel's treatises, though they were part of the collection of the largest European libraries in the 19th century, were only rediscovered in 1900, 16 years after his death. Mendel's revolutionary ideas would have given greater strength to the formulation of Charles Darwin's ideas about common descent and gradual evolution through natural selection presented in 1859 in "The Origin of Species." However, Darwin was not totally ignorant of the possibility of genetic heredity. He even described “invisible characters” emerging in atavistic situations and named his hypothet...
Bioprocessos e Biotecnologia
Este livro, escrito por renomados professores e pesquisadores, apresenta temas relevantes relacionados ao curso de Engenharia de Bioprocessos e Biotecnologia, como engenharia de produção, recuperação e purificação de bioprodutos, as biotransformações, passando pela microbiologia ambiental, a biotecnologia aplicada, a bioenergia, e a biorrefinaria, atingindo tópicos específicos sobre enzimas, edição genômica, vacinas, tecnologias inovadoras, engenharia genética e toxicológica. O curso de Engenharia de Bioprocessos e Biotecnologia é multidisciplinar, e até o presente momento há uma carência de bibliografias específicas para esta graduação que tragam informações que ence...
Zinc Signaling
This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
Monitoring functional groups of herbivorous reef fishes as indicators of coral reef resilience : a practical guide for coral reef managers in the Asia Pacific region
"This document provides practical advice to field practitioners based on an example from the Asia Pacific Region. Key functional groups of herbivores are identified, species are assigned to each functional group, and methods are provided for monitoring their abundance, biomass and size structure ... This document represents the first attempt to develop a monitoring program that is specifically designed to monitor key functional groups of herbivorous reef fishes as indicators of coral reef resilience. Even though it is based on the best available information, it is important to remember that the science underpinning these methods is still new and developing. Further research is now required to address knowledge gaps and refine monitoring methods"--Executive summary.
Repetitive DNA
The experimental data that have been generated using new molecular techniques associated with the completion of genome projects have changed our perception of the structural features, functional implications and evolutionary dynamics of repetitive DNA sequences. This volume of Genome Dynamics provides a valuable update on recent developments in research into multigene families, centromeres, telomeres, microsatellite DNA, satellite DNA, and transposable elements. Each chapter presents a review by distinguished experts and analyzes repetitive DNA diversity and abundance, as well as the impact on genome structure, function and evolution. This publication is targeted at scientists and scholars at every level, from students to faculty members, and, indeed, anyone involved or interested in genetics, molecular evolution, molecular biology as well as genomics will find it a valuable source of up-to-date information.
MOLECULAR SYSTEMATICS
Leading scientists provide the most up-to-date information.This richly detailed book is the first complete review of molecular systematics and phylogeography of mollusks. Ten chapters cover a full range of issues such as research opportunities, molecules and evolution, bivalve evolution, gastropod evolution, and how mollusks have evolved into so many species. The concluding title in the Smithsonian Series of Comparative Evolutionary Biology, this book brings together experts from around the world. Each explores their topic in a way that reveals not only the evolutionary history of mollusks, but also how evolution operates. Anyone seriously interested in living mollusks, fossilized shells, or evolution will find this book to be an invaluable resource.
Ethics of Animal Use
An interesting and accessible introduction to ethical issues raised by various forms of human use of animals. This textbook avoids moral lecturing and presents a range of ethical viewpoints without defending or applying any specific stance. Readers are encouraged and provoked to reflect for themselves, and to sharpen their own points of view regarding the ethical limits on our use of animals. They will also gain further understanding of the views held by other people. Early chapters of this interdisciplinary book cover changes over time in our view of animals, the principles of animal ethics, and different views of what counts as a good animal life. Later chapters apply the conceptual tools ...
Copper-Catalyzed Multi-Component Reactions
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Nanocosmetics and Nanomedicines
The book "Nanocosmetics and nanomedicines: new approaches for skin care” contains a summary of the most important nanocarriers for skin delivery. Although “nanocosmetics” is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject “nanocosmetics”. The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.
Melatonin and Melatonergic Drugs in Clinical Practice
The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson’s disease, Alzheimer’s disease. Additionally, melatonin’s therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin’s antioxidant role...
