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PHealth 2016
Smart mobile systems, eHealth and telemedicine, as well as social media and gamification, have all become important enablers for the provision of the next generation of health services. This book presents the proceedings of the 13th International Conference on Wearable, Micro and Nano Technologies for Personalised Health (pHealth 2016), held in Heraklion, Crete, in May 2016. pHealth 2016 brings together experts from medical, technological, political, administrative, legal and social domains with the aim of further emphasizing the integration of biology and medical data, systems and information using mobile technologies. The book includes two keynotes and two specially invited talks as well a...
Validation and Verification of Predictive Salivary Biomarkers for Oral Health
Abstract: Oral health is important not only due to the diseases emerging in the oral cavity but also due to the direct relation to systemic health. Thus, early and accurate characterization of the oral health status is of utmost importance. There are several salivary biomarkers as candidates for gingivitis and periodontitis, which are major oral health threats, affecting the gums. These need to be verified and validated for their potential use as differentiators of health, gingivitis and periodontitis status, before they are translated to chair-side for diagnostics and personalized monitoring. We aimed to measure 10 candidates using high sensitivity ELISAs in a well-controlled cohort of 127 ...
Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring
Abstract: This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis reveal...
Automated Pre-analytic Processing of Whole Saliva Using Magnet-beating for Point-of-care Protein Biomarker Analysis
Abstract: Saliva offers many advantages for point-of-care (PoC) diagnostic applications due to non-invasive, easy, and cost-effective methods of collection. However, the complex matrix with its non-Newtonian behavior and high viscosity poses handling challenges. Several tedious and long pre-analytic steps, incompatible with PoC use, are required to liquefy and homogenize saliva samples before protein analysis can be performed. We apply magnet-beating to reduce hands-on time and to simplify sample preparation. A magnet in a chamber containing the whole saliva is actuated inside a centrifugal microfluidic cartridge by the interplay of centrifugal and magnetic forces. Rigorous mixing, which hom...
Seminar I
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Citizens as Partners
Governments are in a crisis of identity, some would say legitimacy, with election turnouts low in many OECD countries and a widespread feeling of disenchantment among citizens with government and the democratic process. Can governments do something to change this? Certainly, doing nothing is not an answer. What every country needs is more transparency, more consultation and more participation. This book is a unique source of comparative information on this challenging subject. It examines a wide range of country experiences, offers examples of good practice, highlights innovative approaches and identifies promising tools (including new information technologies). A set of ten guiding principl...
Gesamteuropa
In diesem Sammelband werden auf der Grundlage der jüngeren historischen Ent wicklungen Möglichkeiten und Grenzen für die Schaffung eines gemeinsamen Eu ropa untersucht. Ziel des Bandes ist es, eine solide und umfassende Grundlage für zukünftige Diskussionen zu liefern, eine Art Handbuch also, das für Schüler und Studenten ebenso nützlich ist wie für Politiker und Wissenschaftler. All diejenigen, die sich mit den komplexen Fragen des gesamteuropäischen Entwicklungsprozesses auseinandersetzen wollen, waren bisher auf mehr oder minder zufällig verfügbare Analysen verwiesen. Dieser Band will dazu beitragen, Lücken zu schließen. Der Begriff >Gesamteuropa« ist diffus. Er kann geogra...
OECD Working Papers
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