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Challenges in Identifying Antibiotic Resistance Targets for Point-of-care Diagnostics in General Practice
Abstract: General practitioners stand at the front line of healthcare provision and have a pivotal role in the fight against increasing antibiotic resistance. In this respect, targeted antibiotic prescribing by general practitioners would help reduce the unnecessary use of antibiotics, leading to reduced treatment failures, fewer side-effects for patients and a reduction in the (global) spread of antibiotic resistances. Current 'gold standard' antibiotic resistance detection strategies tend to be slow, taking up to 48 h to obtain a result, although the implementation of point-of-care testing by general practitioners could help achieve the goal of targeted antibiotic prescribing practices. However, deciding on which antibiotic resistances to include in a point-of-care diagnostic is not a trivial task, as outlined in this publication
Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring
Abstract: This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis reveal...
World Report 2019
The best country-by-country assessment of human rights. The human rights records of more than ninety countries and territories are put into perspective in Human Rights Watch's signature yearly report. Reflecting extensive investigative work undertaken by Human Rights Watch staff, in close partnership with domestic human rights activists, the annual World Report is an invaluable resource for journalists, diplomats, and citizens, and is a must-read for anyone interested in the fight to protect human rights in every corner of the globe.
Fast Food Nation
An exploration of the fast food industry in the United States, from its roots to its long-term consequences.
World Report 2020
The best country-by-country assessment of human rights. The human rights records of more than ninety countries and territories are put into perspective in Human Rights Watch's signature yearly report. Reflecting extensive investigative work undertaken by Human Rights Watch staff, in close partnership with domestic human rights activists, the annual World Report is an invaluable resource for journalists, diplomats, and citizens, and is a must-read for anyone interested in the fight to protect human rights in every corner of the globe.
Cage-busting Leadership
Based on interviews with hundreds of teachers, teacher advocates, union leaders, and others, Hess identifies the challenges teachers face, seeks concrete and workable solutions, and offers recommendations to put those solutions in place. A uniquely practical and inspiring book, The Cage-Busting Teacher is for educators who want to shape the schools and systems in which they work. "The Cage-Busting Teacher is filled with practical ideas on how teachers can lead outside of the classroom to create school environments where they are free to do their best work. This book is a must-read for all teachers and school leaders."
The Role of New Technologies in Medical Microbiological Research and Diagnosis
This e-book provides a comprehensive overview of state of the art applications of biomolecular techniques that are currently used, or are in development in the field of microbiological diagnostics research. In this respect, the topics covered include, genomics, proteomics, immunologics, biosensors, microarrays and nano-culture technologies. The broad range of techniques covered by the book will be invaluable to readers from professions allied to (but not exclusive to) microbiology analysts and researchers, laboratory technicians, (medical) microbiologists, molecular biologists, analytical phys.
The Fungal Cell Wall
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Composite Bow
An ancient design, emerging from Central Asia in the second millennium BC, the composite bow was adopted by a staggering variety of cultures, from nomadic tribal peoples such as the Huns, Turks and Mongols, to mighty empires such as the Romans, Byzantines, Persians, Arabs and Chinese. Offering high power and portability, the composite bow was an ideal cavalry weapon, though it was also used by infantry in open battle and as a siege weapon. In this important study, an expert on Eastern military technology tells the story of this extraordinary piece of military hardware; how it was made and how various cultures developed differing tactics for using it. He explains why the composite bow achieved such stunning successes and how it endured as a weapon of choice for thousands of years.
