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Pragmatics across Languages and Cultures
This handbook provides a comprehensive overview, as well as breaking new ground, in a versatile and fast growing field. It contains four sections: Contrastive, Cross-cultural and Intercultural Pragmatics, Interlanguage Pragmatics, Teaching and Testing of Second/Foreign Language Pragmatics, and Pragmatics in Corporate Culture Communication, covering a wide range of topics, from speech acts and politeness issues to Lingua Franca and Corporate Crises Communication. The approach is theoretical, methodological as well as applied, with a focus on authentic, interactional data. All articles are written by renowned leading specialists, who provide in-depth, up-to-date overviews, and view new directions and visions for future research.
Historical Theory
Practising historians claim that their accounts of the past are something other than fiction, myth or propaganda. Yet there are significant challenges to this view, most notably from postmodernism. In Historical Theory, a prominent historian develops a highly original argument that evaluates the diversity of approaches to history and points to a constructive way forward. Mary Fulbrook argues that all historians face key theoretical questions, and that an emphasis on the facts alone is not enough. Against postmodernism, she argures that historical narratives are not simply inventions imposed on the past, and that some answers to historical questions are more plausible or adequate than others. Illustrated with numerous substantive examples and its focus is always on the most central theoretical issues and on real strategies for bridging the gap between the traces of the past and the interpretations of the present. Historical Theory is essential and enlightening reading for all historians and their students.
Nucleic Acids Chemistry
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.
Pedagogical Partnerships
Pedagogical Partnerships and its accompanying resources provide step-by-step guidance to support the conceptualization, development, launch, and sustainability of pedagogical partnership programs in the classroom and curriculum. This definitive guide is written for faculty, students, and academic developers who are looking to use pedagogical partnerships to increase engaged learning, create more equitable and inclusive educational experiences, and reframe the traditionally hierarchical structure of teacher-student relationships. Filled with practical advice, Pedagogical Partnerships provides extensive materials so that readers don't have to reinvent the wheel, but rather can adapt time-tested and research-informed strategies and techniques to their own unique contexts and goals.
National Statement on Ethical Conduct in Human Research 2023
"The purpose of the National Statement is to promote ethically good human research. Fulfilment of this purpose requires that participants be accorded the respect and protection that is due to them. It also involves the fostering of research that is of benefit to the community. The National Statement is therefore designed to clarify the responsibilities of: institutions and researchers for the ethical design, conduct and dissemination of results of human research ; and review bodies in the ethics review of research. The National Statement will help them to meet their responsibilities: to identify issues of ethics that arise in the design, review and conduct of human research, to deliberate about those ethical issues, and to justify decisions about them"--Page 6.
Design and Delivery of SiRNA Therapeutics
This volume details protocols on rationale design of therapeutic siRNA molecules and its encapsulation with smart vehicles to overcome the barriers to an effective administration in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Design and Delivery of SiRNA Therapeutics aims to ensure successful results in the further study of this vital field. This volume details protocols on rationale design of therapeutic ...
Human Cancer
A summary of the epidemiology of human cancer.
Fools and Folly
The Fool in the Middle Ages and Early Modern period was either a person who capitalized on his natural deficiencies, which were then considered amusing, or a professional entertainer the artificial Fool who specialized in clowning. His distinctive clothing and bauble are known to us through numerous Psalter illustrations where he is shown in connection with Psalm 52, which asserts that The fool has said in his heart there is no God. Attitudes toward the Fool varied, but his place was to become assured on stage, where his role is best known to us through the plays of Shakespeare. The articles in the present volume provide indispensable analyses of the Fool from a number of different perspectives.
Targeted Molecular Imaging
Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies t
