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Abstract: Introduction: Based on extracorporeal circulation, targeted reperfusion strategies have been developed to improve survival and neurologic recovery in refractory cardiac arrest: Controlled Automated Reperfusion of the whoLe Body (CARL). Furthermore, animal and human cadaver studies have shown beneficial effects on cerebral pressure due to head elevation during conventional cardiopulmonary resuscitation. Our aim was to evaluate the impact of head elevation on survival, neurologic recovery and histopathologic outcome in addition to CARL in an animal model. Methods: After 20 min of ventricular fibrillation, 46 domestic pigs underwent CARL, including high, pulsatile extracorporeal blood...
As computer and space technologies have been developed, geoscience information systems (GIS) and remote sensing (RS) technologies, which deal with the geospatial information, have been rapidly maturing. Moreover, over the last few decades, machine learning techniques including artificial neural network (ANN), deep learning, decision tree, and support vector machine (SVM) have been successfully applied to geospatial science and engineering research fields. The machine learning techniques have been widely applied to GIS and RS research fields and have recently produced valuable results in the areas of geoscience, environment, natural hazards, and natural resources. This book is a collection representing novel contributions detailing machine learning techniques as applied to geoscience information systems and remote sensing.
Bridge cranes are widely used as discontinuous material handling systems in industrial environments. The so-called crane bridge plays a central role in the overall construction. With increasing span widths and load capacities, the dimensions of the crane bridge also increase. The core of this work is the design and optimization of a new type of bridge crane system, which consists of individual segments and is eccentrically pretensioned by a tensile member.
Inhaltsangabe:Abstract: Skeletal muscle is a complex and heterogeneous tissue capable of remarkable adaptation in response to various stimuli such as exercise training. Molecular biology approaches have made a large contribution to our current understanding of how mechanical loading can alter gene expression and muscle protein synthesis rates in skeletal muscle. The steady-state level of a given mRNA is a function of both its rate of synthesis and its rate of degradation, implying that the rate of change in response to a cellular stimulus is dependent on the dynamics of mRNA turnover. Changes in muscle mRNA steady-state levels can be taken as an index of changes in gene expression, constitut...
Just like a phantom, the topic of »gene doping« keeps haunting the debates regarding the future of competitive sports for years. Very often, corresponding fantasies and visions culminate in the imagination of super athletes who are permanently manipulated with regard to their genetic disposition. However, the application scenarios to be expected will be far more unspectacular, but more probable and more obvious at the same time. Very soon, we will have to expect the use of new substances as well as of methods in gene and cell therapy for targeted manipulation of gene activity. Their use promises a highly efficient performance enhancement and will be difficult to prove, if at all. This book provides comprehensive answers to the key questions of the further development: Which scientific results could cater to the needs of potential gene doping? Where are the future gateways in top-level and popular sports? And how can prohibitions and monitoring be used in responding to this? Another question will be which individual behavioural patterns of athletes and which social contexts will play a role with regard to the potential »career« of gene doping.
Recent advances have contributed to our understanding of how a plant-based diet confers many health advantages and how substances from plants may be effective in the prevention of specific cancers. The Ninth Annual Research Conference of the American Institute for Cancer Research has focused on the latest developments in several categories of nutrients of wide contemporary interests. The conference sessions included such topics as the effects of soy, green tea, selenium, wine, grapes, and spices in cancer prevention. This conference was held in Washington, D.C. on September 2nd and 3rd, 1999, and was entitled Nutrition and Cancer Prevention: New Insights Into the Roles of Phytochemicals. The discussion program included a session that was devoted to the current status of herbal products in relation to cancer prevention, in recognition of the increasing attention that complementary and alternative medicine has been receiving from the scientific community as well as the general public. A separate presentation addressed the issue of nutritional supplements and cancer prevention.