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Bioactive Compounds of Jaboticaba (Plinia sp.)
The whole jaboticaba fruit stood out for its high levels of total polyphenols, mainly anthocyanins (cyanidin and delphinidin), ellagic acid, methylellagic acid, gallic acid, myricetin, quercetin, castalagin, pedunculagin and vescalagin. When evaluating the behavior of these compounds after in vitro digestion, it is observed that anthocyanins did not suffer as much in the salivary and gastric stages, but showed a significant reduction after the intestinal stage. However, a significant reduction in hydrolysable tannins was reported, but the hydrolysis of these compounds reflected an increase in gallic and ellagic acids contents. Plinia sp. presents moderate levels of carotenoids, but, only lutein and ß-carotene are found. In addition, no studies were identified that evaluated the bioavailability of these compounds in this food matrix.
Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
XXVI Brazilian Congress on Biomedical Engineering
This volume presents the proceedings of the Brazilian Congress on Biomedical Engineering (CBEB 2018). The conference was organised by the Brazilian Society on Biomedical Engineering (SBEB) and held in Armação de Buzios, Rio de Janeiro, Brazil from 21-25 October, 2018. Topics of the proceedings include these 11 tracks: • Bioengineering • Biomaterials, Tissue Engineering and Artificial Organs • Biomechanics and Rehabilitation • Biomedical Devices and Instrumentation • Biomedical Robotics, Assistive Technologies and Health Informatics • Clinical Engineering and Health Technology Assessment • Metrology, Standardization, Testing and Quality in Health • Biomedical Signal and Image Processing • Neural Engineering • Special Topics • Systems and Technologies for Therapy and Diagnosis
Principles and concepts for development in nowadays society
Temos o prazer de lançar o primeiro livro internacional do ano de 2022 voltado a área do desenvolvimento, que tem como título Principles and concepts for development in nowadays society, essa obra contém 152 artigos voltados a área multidisciplinar, sendo a mesma pela Seven Publicações Ltda. A Seven Editora, agradece e enaltasse os autores que fizeram parte desse livro. Desejamos uma boa leitura a todos
OECD Public Governance Reviews The Innovation System of the Public Service of Brazil An Exploration of its Past, Present and Future Journey
Governments must innovate if they are to be effective. In a world of change, a government that stands still will soon be overtaken by events and shifting citizen expectations. This report explores the past, present and possible future journey of the innovation system of the Brazilian public service.
Modernity in Black and White
Modernity in Black and White provides a groundbreaking account of modern art and modernism in Brazil. Departing from previous accounts, mostly restricted to the elite arenas of literature, fine art and architecture, the book situates cultural debates within the wider currents of Brazilian life. From the rise of the first favelas, in the 1890s and 1900s, to the creation of samba and modern carnival, over the 1910s and 1920s, and tracking the expansion of mass media and graphic design, into the 1930s and 1940s, it foregrounds aspects of urban popular culture that have been systematically overlooked. Against this backdrop, Cardoso provides a radical re-reading of Antropofagia and other modernist currents, locating them within a broader field of cultural modernization. Combining extensive research with close readings of a range of visual cultural production, the volume brings to light a vast archive of art and images, all but unknown outside Brazil.
International Arbitration: Law and Practice
International Arbitration: Law and Practice (Third Edition) provides comprehensive and authoritative coverage of the basic principles and legal doctrines, and the practice, of international arbitration. The book contains a systematic, but concise, treatment of all aspects of the arbitral process, including international arbitration agreements, international arbitral proceedings and international arbitral awards. The Third Edition guides both students and practitioners through the entire arbitral process, beginning with drafting, enforcing and interpreting international arbitration agreements, to selecting arbitrators and conducting arbitral proceedings, to recognizing, enforcing and seeking ...
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