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Mapping the Origin and Fate of Myeloid Cells in Distinct Compartments of the Eye by Single-cell Profiling
Abstract: Similar to the brain, the eye is considered an immune-privileged organ where tissue-resident macrophages provide the major immune cell constituents. However, little is known about spatially restricted macrophage subsets within different eye compartments with regard to their origin, function, and fate during health and disease. Here, we combined single-cell analysis, fate mapping, parabiosis, and computational modeling to comprehensively examine myeloid subsets in distinct parts of the eye during homeostasis. This approach allowed us to identify myeloid subsets displaying diverse transcriptional states. During choroidal neovascularization, a typical hallmark of neovascular age-related macular degeneration (AMD), we recognized disease-specific macrophage subpopulations with distinct molecular signatures. Our results highlight the heterogeneity of myeloid subsets and their dynamics in the eye that provide new insights into the innate immune system in this organ which may offer new therapeutic targets for ophthalmological diseases
Bacteria and Intracellularity
Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria. This book offers a wide-ranging look at the latest studies, including: foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota infections of the urogenital tract, endothelial barriers, and the nervous system major advances in work with ...
Does Development Aid Affect Conflict Ripeness?
Many developing countries find themselves in seemingly intractable internal conflicts, hindering them from moving on into a more stable, secure and wealthy environment. It seems that underdevelopment and conflict go hand in hand. Underdevelopment most often implies large streams of development aid channeled into countries at war. The work evaluates to what extent an increase in development aid affects conflict ripeness. The research shows that the effect is ambivalent: it depends on the conditions of provision whether it is positive or negative. In general, an ‘increase in development aid’ decreases the intensity of one of the ingredients to conflict ripeness: the mutually hurting stalemate. However, if embedded into a smart strategy, an ‘increase in development aid’ enhances the second ingredient to conflict ripeness: the sense of a way out. By that it counterbalances the negative effect and thus fosters the phase of ripeness, creating an ideal starting position for a subsequent peace process.
Annika Koops
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Reflections on Camps – Space, Agency, Materiality
Camps as a global and ubiquitous mass phenomenon of the present and a flexible isolation tool for/against specific socially, politically, or ethnically defined groups are at the centre of current policies and societal debates. In the present volume, the authors explore camps as (cultural) spaces in a broad sense and deal with their complex dimensions as sites of the Modern. They examine camp spaces and their social configurations, physical/architectural qualities, symbolic functions as well as cultural representations in an intent to define the inscribed ambivalences, inconsistencies and paradoxes of the phenomenon. Positioned within different disciplinary contexts (Contemporary History, Vis...
Annika
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Annika
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Nachtfahrt
Wie willst du ein mörderisches Spiel gewinnen, ohne die Regeln zu kennen? Die Nachricht vom Unfalltod ihres Vaters ist ein Schock für Katharina Holten. Nicht nur muss sie nach Hause zurückkehren und sich um die Fahrschule des Vaters kümmern, sie sieht sich auch mit dem Ereignis konfrontiert, das ihr Leben Jahre zuvor vollkommen auf den Kopf gestellt hat. Da verschwindet ihre Nichte Ronja. Wenn es Katharina nicht gelingt, herauszufinden, was das mit der Geschichte ihrer Familie zu tun hat, droht das junge Mädchen getötet zu werden. Eine atemlose Jagd gegen die Zeit beginnt ... Ein packender Psychothriller über ein tödliches Familiengeheimnis. »Ich konnte nicht aufhören zu lesen – spannende Charaktere, ungewöhnliches Setting und fiese Cliffhanger!« Ivar Leon Menger.
Hochstrittige Eltern
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