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We are delighted to present the inaugural Frontiers in Cardiovascular Medicine “Rising Stars” article collection. This collection showcases the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers were individually nominated by the Chief Editors of the Journal in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of cardiovascular medicine, including the elucidation of fundamental biology, the development of novel diagnostics or therapeutics, computational modelling approaches, and bioengineering strategies for regeneration.
Mitochondrial biology reinvented itself and became a new world that has attracted new scientists influencing every field of biomedical research. Mitochondrial research is growing and changing, as reflected by the exponential rise in the number of conferences covering mitochondrial biology and the role of mitochondria in diseases ranging from neurodegenerative diseases,metabolic diseases and genetic muscular dystrophies toimmunopathologies and cancer. As the awareness of the essential role of mitochondria in pathology rose, a demand for new approaches to measure mitochondrial function resulted in the robust development of new forms of microscopy and spectroscopy that opened windows into previ...
This volume focuses on the huge advances in the last 25 years on the use of this animal model for biomedical research (cancer, heart disease and neurodegeneration), fundamental neuroscience and basic subterranean biology. In 2013, Science magazine named the naked mole-rat as the Vertebrate of the Year. This was partly due to research carried out documenting its extreme longevity, negligible senescence, and prolonged maintenance of cancer free, good health well into old age as well as seminal work on mechanisms involved in these processes, pain and hypoxia resistance. In addition to this research focus on longevity and chronic diseases such as cancer and cardiovascular disease, the naked mole-rat has also made a substantial contribution to the fields of ecophysiology, neuroscience and behavior. With international contributions, this book provides a valuable text for zoological students, behavioral scientists and biomedical researchers.
Inequality has drastically increased in many countries around the globe over the past three decades. The widening gap between the very rich and everyone else is often portrayed as an unexpected outcome or as the tradeoff we must accept to achieve economic growth. In this book, three International Monetary Fund economists show that this increase in inequality has in fact been a political choice—and explain what policies we should choose instead to achieve a more inclusive economy. Jonathan D. Ostry, Prakash Loungani, and Andrew Berg demonstrate that the extent of inequality depends on the policies governments choose—such as whether to let capital move unhindered across national boundaries...
Upscaling, Training, Commoning features a lively account of the 10-year exploration by STEALTH.unlimited into what it means to engage with the glimpses of a world that has become conceivable in the cracks of the Global Financial Crisis (2008). Ultimately, this book is about devising methods for imagining and enacting other worlds. The perspective for this is situated between spatial practice and emerging commons, between an already plundered future and the politics of possibility, between reflection and future fiction. The book traces the moves STEALTH.unlimited (Ana Dzokić and Marc Neelen) have taken to reframe practice, to rethink economy and create urban commons. Its six-part sequence mo...
Is red wine good for you? And if so, why? How much? And what are the actual benefits? This addition to the SpringerBriefs in Cell Biology series thoroughly but succinctly answers these questions. It covers the biochemistry, health benefits and therapeutic potential of wine grapes. It begins with an overview of phytoalexin production in Vitis vinifera (Common Grape Vine), detailing the relationship of resveratrol to analogues such as pterostilbene, piceid and the viniferins (resveratrol oligomers). The discussion then turns to the hundreds of reports linking resveratrol and related grape vine polyphenols to various beneficial health effects especially cardio- and cerebro- vascular, metabolic, anti-inflammatory and more. Also addressed are the numerous intracellular mechanisms that have been shown to mediate the effects of these compounds in mammalian cells and tissues. Finally, the authors discuss aspects of polyphenol bioavailability and how this will influence choices taken for delivering these compounds as nutritional supplements. A brief chapter containing general conclusions and prospectus rounds out the information.
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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health a...