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Eva Maria Kentner
None
Beta-Catenin and Ha-ras - Master Regulators of Zonal Gene Expression in Mouse Liver?
Hepatocytes located in the periportal or perivenous regions of the liver lobule have different, often complementary functions, as indicated by differences in the content and activity of various enzymes of the intermediary and xenobiotic metabolism. The signaling molecules mediating this metabolic zonation, however, are largely unknown. Based on the correlation of marker protein expression between perivenous hepatocytes and Ctnnb1 (encoding beta-catenin)-mutated mouse hepatomas and between periportal hepatocytes and Ha-ras-mutated hepatomas, a hypothesis was developed postulating that two opposing signals, a Wnt-signal maybe delivered by endothelial cells of the central veins activating a bet...
Eva-Maria
None
Advances in Geroscience
This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of...
Neurodegeneration in Multiple Sclerosis
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Cancer-Associated Thrombosis
Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides
