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Allogeneic Transplant Procurement in the Times of COVID-19: Quality Report from the Central European Cryopreservation Site
Background: Because of limitations of transportation imposed by the COVID-19 pandemic, current recommendation calls for cryopreservation of allogeneic stem cell transplants before patient conditioning. A single cell therapy laboratory was selected to function as the central cryopreservation hub for all European registry donor transplants intended for the Australian-Pacific region. We examined properties of these transplants to ascertain how quality is maintained. Methods: We analyzed 100 pandemic-related allogeneic mobilized blood-derived stem cell apheresis products generated at 30 collection sites throughout Europe, shipped to and cryopreserved at our center between April and November of 2...
Accurate Quantification of Chromosomal Lesions Via Short Tandem Repeat Analysis Using Minimal Amounts of DNA
Abstract: Background Cytogenetic aberrations such as deletion of chromosome 5q (del(5q)) represent key elements in routine clinical diagnostics of haematological malignancies. Currently established methods such as metaphase cytogenetics, FISH or array-based approaches have limitations due to their dependency on viable cells, high costs or semi-quantitative nature. Importantly, they cannot be used on low abundance DNA. We therefore aimed to establish a robust and quantitative technique that overcomes these shortcomings. Methods For precise determination of del(5q) cell fractions, we developed an inexpensive multiplex-PCR assay requiring only nanograms of DNA that simultaneously measures allel...
The Bug Club
In The Bug Club, Elise Gravel shares all her favourite and most interesting facts about these marvelous creatures, some of which are so unique and strange, you could almost imagine them living in outer space! Most people know that spiders have eight eyes, but what about the caterpillar? These little critters have them beat with a whopping twelve! Did you know mosquitoes are attracted to smelly feet? That the honey bee has hair on her eyeballs? That butterfly feet double as noses? And grasshoppers have ears on their bellies? These are just some of the many things about bugs that make them endlessly enchanting. Elise’s inquisitiveness and charm pop off the page as she takes us on a walk thro...
Infested
Bed bugs are thriving across the globe--from North and South America, to Africa, Asia and Europe. For some time, bed bugs were naively seen as a problem unique to developing countries, but their love of high thread content sheets has set them up in five-star residences in the United States, Canada, the United Kingdom, and other parts of Europe as well. Bed Bugs were first noticed in society by Americans in the early 1700 s. Many believe sailboats returning from Europe unknowingly carried the bugs as cargo, as sailors complained of being attacked as they slept in their cabins. With the introduction of DDT in the 1950s, bed bugs nearly disappeared. But when DDT was banned in the 1970 s, a wave...
Peanut-Head Bugs
Introduces the insects of the Fulgoridae family, which live on the sap of Central and South American simaruba trees and are sometimes called peanut-head bugs.
Acute Myeloid Leukemia
This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults. The opening chapters present current knowledge of epidemiology, etiologic factors, and the pathogenesis and molecular development of AML. Detailed guidance is offered on laboratory and clinical diagnostic workup and disease classification, and the patient- and disease-related factors that determine prognosis and treatment allocation are identified. On the basis of these general considerations, initial treatments in patients considered fit for intensive treatment and in older and co-morbid patients are reviewed, and the available relap...
Roald Dahl's James's Giant Bug Book
Looking for the perfect Easter activity for your animal and bug loving readers? Enter the world of James and the Giant Peach, and head off on an incredible insect adventure. Now you can join James, The Centipede, The Earthworm and the rest of the gang in this bug-packed journey through the world of insects. Perfect for Easter holiday activities; get your hands marvellously muddy and find out all the whacky and wondrous facts about your favourite creepy-crawlies! Based on Roald Dahl's James and the Giant Peach, this phizz-whizzing activity book is packed with brilliant bugs and fun activities to try at home, like making your own ant farm and building your very own bug hotel. What were your children's favourite part of James's Giant Bug Book? Let us know in a review below!
Bugs Vs Humans
Yikes! Spiders! Mites on my eyelashes? Some bugs are harmless, some are just gross and some are downright scary! * Human follicle mites live on the skin of our eyelashes, eyebrows and nose. * The insect population of Earth is estimated to be 10,000,000,000,000,000,000 insects outnumber humans 1,492,000,000 to one. * Fleas are to blame for spreading many diseases, including the famous Black Plague. * The lowly mosquito is responsible for no less than 1.5 million human deaths per year. * In order to match the jump of a froghopper, a human would need to jump 216 meters high. * Watch out when you kill a wasp or an army ant -- the dying bug releases an attack pheromone that alerts its sisters, and a raiding party can number 500,000. * When Human botfly larvae burrow under your skin, the remedy is to block the air hole with tape or petroleum jelly to asphyxiate the larvae. * When ticks gorge themselves on human blood, they can increase 200 to 600 times their original weight -- it's like going for lunch and coming back weighing as much as an elephant! * And so much more…
Nanoparticles in Cancer Therapy
This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance...
Bug Out!
This reader features some of the most disgusting, far-out bugs on the planet. Youngsters learn how a scorpion uses its poison, discover how the jumping spider hunts, and marvel at the weight of the giant weta-punga. Includes a sheet of tattoos. Full color. Consumable.
