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Myelodysplastic Syndromes
This book reviews the standard diagnostic and therapeutic management of patients with myelodysplastic syndromes (MDS) and examines ongoing research developments in the field. The importance of appropriate prognostic stratification, taking into account recent advances in understanding of the molecular pathogenesis of MDS, is explained, and both established and novel treatment approaches are discussed in depth. The coverage includes, for example, the use of erythropoietic stimulating agents, iron chelation therapy, the immunomodulator lenalidomide, hypomethylating agents such as azacitidine, and allogeneic hematopoietic stem cell transplantation. Myelodysplastic syndromes are heterogeneous and...
Accurate Quantification of Chromosomal Lesions Via Short Tandem Repeat Analysis Using Minimal Amounts of DNA
Abstract: Background Cytogenetic aberrations such as deletion of chromosome 5q (del(5q)) represent key elements in routine clinical diagnostics of haematological malignancies. Currently established methods such as metaphase cytogenetics, FISH or array-based approaches have limitations due to their dependency on viable cells, high costs or semi-quantitative nature. Importantly, they cannot be used on low abundance DNA. We therefore aimed to establish a robust and quantitative technique that overcomes these shortcomings. Methods For precise determination of del(5q) cell fractions, we developed an inexpensive multiplex-PCR assay requiring only nanograms of DNA that simultaneously measures allel...
Federal Register
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Protestant Cosmopolitanism and Diplomatic Culture
In Protestant Cosmopolitanism and Diplomatic Culture, Daniel Riches investigates seventeenth-century Brandenburg-Swedish relations to present an image of early modern diplomacy driven by interpersonal networks grounded in their members’ educational backgrounds, intellectual and cultural interests, religious convictions, and personal connections.
The Public/Private Sector Mix in Healthcare Delivery
"This volume examines the public/private sector mix in a number of national healthcare systems and their interface with the goals of health equity and quality of healthcare. Moreover, there is a consideration of public accountability. The unique significance of this collection of national studies involving the public/private sector mix of healthcare services and/or finances is that it provides insights into the factors that enhance the public/private sector mix in fulfilling the goals of health equity and the quality of healthcare services as well as an understanding of the circumstances in which elements of the public/private sector mix may be harmful for the achievement of such goals in a variety of national settings. The contributions to this volume provide a variety of perspectives in dealing with these objectives"--
The Reshaping of West European Party Politics
Reshaping of West European Party Politics offers an empirical study of party politics in Belgium, Denmark, France, Germany, the Netherlands, Sweden and the UK from 1980 and onwards. This book highlights the more complex party system agenda with the decline, but not disappearance, of macroeconomic issues as well as the rise in 'new politics' issues together with education and health care. Moreover, various 'new politics' issues such as immigration, the environment,and European integration have seen very different trajectories.To explain the development of the individual issues, this volume develops a new theoretical model labelled the'issue incentive model' of party system attention. The aim of the model is to explain how much attention issues get throughout the party system, which is labelled 'the party system agenda'.
Healthy or Sick?
Analyses the relation of preventive and curative health policy and its evolution over time.
The Oxford Handbook of the Welfare State
This is the comprehensively-revised second edition of a volume that was welcomed at its first appearance as 'the most authoritative survey and critique of the welfare state yet published'. Its fifty-one chapters have been written by acknowledged experts in the field from across Europe, Australia, and North America. Some chapters are brand new; all have been systematically revised, and they are right up to date. The first seven sections of the book cover the themes of Ethics, History, Approaches, Inputs and Actors, Policies, Policy Outcomes, and Worlds of Welfare. A final chapter is devoted to the future of welfare and well-being under the imperatives of climate change. Every chapter is writt...
