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Accurate Quantification of Chromosomal Lesions Via Short Tandem Repeat Analysis Using Minimal Amounts of DNA
Abstract: Background Cytogenetic aberrations such as deletion of chromosome 5q (del(5q)) represent key elements in routine clinical diagnostics of haematological malignancies. Currently established methods such as metaphase cytogenetics, FISH or array-based approaches have limitations due to their dependency on viable cells, high costs or semi-quantitative nature. Importantly, they cannot be used on low abundance DNA. We therefore aimed to establish a robust and quantitative technique that overcomes these shortcomings. Methods For precise determination of del(5q) cell fractions, we developed an inexpensive multiplex-PCR assay requiring only nanograms of DNA that simultaneously measures allel...
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Myeloische Neoplasien
Eine Übersicht der rasanten Entwicklungen im Bereich der myeloischen Erkrankungen - Dieses Buch stellt kompakt und praxisorientiert aktuelle diagnostische und therapeutische Verfahren dar und bietet so eine gute Unterstützung sowohl bei der Akutversorgung im Krankenhaus als auch bei der langfristigen Betreuung der Patienten im ambulanten Bereich. Neben pathophysiologischen und molekularen Grundlagen und der aktuellen Klassifikation werden auch zukünftige Aspekte der Diagnostik und Therapie myeloischer Neoplasien aufgezeigt.
A Disimprisoned Epic
Thomas Carlyle's history of the French Revolution captured the Victorian imagination with vivid pictures of a society in conflict. A rich, brilliant, and arresting book, it defined a crucial epoch in modern European history for generations of British readers. Nevertheless, The French Revolution has lost not only its general readership but also its academic audience, for it is not history as history is commonly practiced, and it is not literature as literature is commonly understood. Only in the past few decades has this difficult yet rewarding text moved back to the central position it deserves. In A Disimprisoned Epic, Mark Cumming elucidates the formal genesis of the French Revolution in C...
The Theory of Social Democracy
The ascendancy of neo-liberalism in different parts of the world has put social democracy on the defensive. Its adherents lack a clear rationale for their policies. Yet a justification for social democracy is implicit in the United Nations Covenants on Human Rights, ratified by most of the worlds countries. The covenants commit all nations to guarantee that their citizens shall enjoy the traditional formal rights; but they likewise pledge governments to make those rights meaningful in the real world by providing social security and cultural recognition to every person. This new book provides a systematic defence of social democracy for our contemporary global age. The authors argue that the ...
