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Systemic Sclerosis - Recent Advances and New Perspectives
Systemic sclerosis (SSc) is a multisystem autoimmune disease involving vasculopathy and immune activation that leads to the deposition of extracellular matrix and the development of fibrosis, resulting in cardinal clinical problems. Systemic Sclerosis - Recent Advances and New Perspectives provides a comprehensive overview of the pathophysiology, diagnosis, and specific management of the clinical manifestations of SSc. The book addresses the current understanding of the causes and consequences of inflammatory activation, chromosomal instability, and activating factors. Special emphasis is placed on diagnosis, from the recognition of very early systemic sclerosis and consideration of its treatment to diagnostic methods for microvascular and pulmonary involvement. It also highlights the less life-threatening but very common manifestations of bone and skeletal muscle involvement, which affect patient quality of life.
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune d...
Vaccines and Autoimmunity
In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as...
Acute Phase Proteins
The magnitude and rapidity of the changes in the concentrations of APPs, together with their short half-life, suggest an important role for these proteins in the establishment of host defense. APPs are regarded as having general functions in trapping of micro-organisms and their products, in activating complement, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free radicals, and in modulating the hosts immune response. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their function during health and disease remains incompletely defined.
Drug-Acceptor Interactions
Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.
Imaging in Rheumatology
'Imaging in Rheumatology' provides a unique, comprehensive review of the modalities of imaging now available to assist rheumatologists in diagnosing and managing virtually all rheumatic diseases. It is divided into three sections. The first describes in simple detail how the various modes of imaging work in practice. The second informs the reader about the use of imaging in the diagnosis of common problems. The final section provides a detailed assessment of the use of imaging in the management of the common rheumatic diseases. The clinical chapters are written by both rheumatologists and radiologists and this combined approach ensures a thorough preview of each topic explaining just what modern imaging can do to help the clinicians diagnose and manage the broad array of rheumatolgical diseases.
Oxford Handbook of Psychiatry
The book is a pocket sized guide providing detailed and comprehensive coverage of clinical psychiatry. Useful to medical trainees in psychiatry and preparing for exams. Its detail and clinical coverage mean it can continue to be used by junior psychiatric trainees and those entering individual psychiatric sub-specialties later in training.
Alcohol, Gender and Drinking Problems
This book is the product of a multinational research project on "Gender, Alcohol and Culture: an International Study" (GENACIS). GENACIS is a major collaborative effort to highlight the relationship between gender and alcohol issues, seek greater understanding of male and female differences in patterns of drinking and alcohol problems, and assess the public health implications of drinking by men and women. Each of the eight country-specific chapters in this volume (Argentina, Brazil, Costa Rica, India, Mexico, Nigeria, Sri Lanka, Uganda) consists of a review of alcohol and alcohol policy in the country and an analysis of social and health problems associated with drinking. For several of the countries, this is the first systematic attempt to provide a broad insight into gender issues and how they relate to alcohol problems. In an era of growing consumption and increasing burden of alcohol-related problems in many developing countries, the findings reported in this book and the GENACIS project in general, are a major step forward in the understanding of the role of gender in alcohol behaviours.
Microwaves in Catalysis
A comprehensive overview covering the principles and preparation of catalysts, as well as reactor technology and applications in the field of organic synthesis, energy production, and environmental catalysis. Edited and authored by renowned and experienced scientists, this reference focuses on successful reaction procedures for applications in industry. Topics include catalyst preparation, the treatment of waste water and air, biomass and waste valorisation, hydrogen production, oil refining as well as organic synthesis in the presence of heterogeneous and homogeneous catalysts and continuous-flow reactions. With its practical relevance and successful methodologies, this is a valuable guide for chemists at universities working in the field of catalysis, organic synthesis, pharmaceutical or green chemistry, as well as researchers and engineers in the chemical industry.
