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Systemic Sclerosis - Recent Advances and New Perspectives
Systemic sclerosis (SSc) is a multisystem autoimmune disease involving vasculopathy and immune activation that leads to the deposition of extracellular matrix and the development of fibrosis, resulting in cardinal clinical problems. Systemic Sclerosis - Recent Advances and New Perspectives provides a comprehensive overview of the pathophysiology, diagnosis, and specific management of the clinical manifestations of SSc. The book addresses the current understanding of the causes and consequences of inflammatory activation, chromosomal instability, and activating factors. Special emphasis is placed on diagnosis, from the recognition of very early systemic sclerosis and consideration of its treatment to diagnostic methods for microvascular and pulmonary involvement. It also highlights the less life-threatening but very common manifestations of bone and skeletal muscle involvement, which affect patient quality of life.
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune d...
Advances in Chronic Pain Treatment
Chronic pain is a complex and multifaceted condition affecting millions worldwide. This type of pain persists for more than three months and can be debilitating and profoundly affect an individual's quality of life. The understanding of the pathophysiology of chronic pain has advanced considerably in recent decades, providing a solid basis for the development of new therapies and therapeutic approaches. Neuroscience has played a key role in these advances, providing a deeper understanding of how the brain and central nervous system process pain, serving as a nexus for multiple disciplines to integrate in addressing this pathology. This Research Topic aims to address the most recent advances in the treatment of chronic pain, both primary and secondary (excluding low back pain, see footnote) by highlighting innovative therapies, advances in neuroscience, long-term pain management, and recent research in the field. With this focus, we hope to shed light on new strategies that could improve the lives of those suffering from chronic pain.
Vaccines and Autoimmunity
In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as...
IL-1 Inhibition
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
ADHD in Adults
Providing a new perspective on ADHD in adults, this compelling book analyzes findings from two major studies directed by leading authority Russell A. Barkley. Groundbreaking information is presented on the significant impairments produced by the disorder across major functional domains and life activities, including educational outcomes, work, relationships, health behaviors, and mental health. Thoughtfully considering the treatment implications of these findings, the book also demonstrates that existing diagnostic criteria do not accurately reflect the way ADHD is experienced by adults, and points the way toward developing better criteria that center on executive function deficits. Accessible tables, figures, and sidebars encapsulate the study results and methods.
Oxford Handbook of Psychiatry
The book is a pocket sized guide providing detailed and comprehensive coverage of clinical psychiatry. Useful to medical trainees in psychiatry and preparing for exams. Its detail and clinical coverage mean it can continue to be used by junior psychiatric trainees and those entering individual psychiatric sub-specialties later in training.
Imaging in Rheumatology
'Imaging in Rheumatology' provides a unique, comprehensive review of the modalities of imaging now available to assist rheumatologists in diagnosing and managing virtually all rheumatic diseases. It is divided into three sections. The first describes in simple detail how the various modes of imaging work in practice. The second informs the reader about the use of imaging in the diagnosis of common problems. The final section provides a detailed assessment of the use of imaging in the management of the common rheumatic diseases. The clinical chapters are written by both rheumatologists and radiologists and this combined approach ensures a thorough preview of each topic explaining just what modern imaging can do to help the clinicians diagnose and manage the broad array of rheumatolgical diseases.
Drug-Acceptor Interactions
Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.
