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Systems Pharmacology and Pharmacodynamics
While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Learning from the COVID-19 Pandemic
COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts...
Plagued: Surviving A Modern Pandemic
Pandemics cannot be eliminated, but they can be stopped; the trick is discovering what will curtail any one particular outbreak. Renowned environmentalist and science writer Albert Bates presents an easy-to-understand scientific overview of the global consequences of pandemics and offers a fresh perspective on how we can coexist with them, individually and collectively. Bates recounts the history of deadly pandemics and provides a basic explanation for why diseases can infect and spread quickly, as well as how viruses invade the body and travel from host to host, further illustrating why we are all at risk. He also reminds us that disrupting natural ecosystems increases the chances of letting loose even more viruses into global populations. Discover which methods have been used to battle infectious outbreaks in the past, which social solutions are the most effective, and how to bolster our resources before the next pandemic strikes.
Biocomputing 2019 - Proceedings Of The Pacific Symposium
The Pacific Symposium on Biocomputing (PSB) 2019 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2019 will be held on January 3 - 7, 2019 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2019 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a...
Sameindalíffræði Tækni II
Síðan í kringum 1960 hafa sameindalíffræðingar þróað aðferðir til að bera kennsl á, einangra og meðhöndla sameindaþátta í frumum þar á meðal DNA, RNA og próteinum. Innihald þessarar bókar: CRISPR genagerð, CRISPR, Prime klippingu, Anti-CRISPR, Transfection, Gen knock-in, Gen knockout, GeneTalk, Haplarithm, Haplarithmisis, Helicase-dependent amplification, Immunoprecipitation, ísólektísk fókus, Isopeptag, Jumping library, Knockout moss, Kodecyte, Kodevirion, Ligasa keðjuverkun, Ligation (sameinda líffræði), Magnet-aðstoðar transfection, MassTag-PCR, Maxam-Gilbert raðgreining, Aðferðir til að rannsaka prótein-prótein víxlverkun, örveru dökkt efni, Mi...
분자 생물학 기술 II
1960 년경부터 분자 생물 학자들은 DNA, RNA 및 단백질을 포함한 세포에서 분자 성분을 식별, 분리 및 조작하는 방법을 개발했습니다 . 이 책의 내용: CRISPR 유전자 편집, CRISPR, Prime 편집, Anti-CRISPR, 형질 감염, 유전자 knock-in, 유전자 knockout, GeneTalk, Haplarithm, Haplarithmisis, Helicase-dependent amplification, Immunoprecipitation, 등전 포커싱, Isopeptag, Jumping library, Knockout moss, Kodecyte, Kodevirion, 리가 제 연쇄 반응, 결찰 (분자 생물학), 자석 보조 transfection, MassTag-PCR, Maxam-Gilbert 시퀀싱, 단백질-단백질 상호 작용을 조사하는 방법, 미생물 암흑 물질, Microsatellite...
Εργαλεία Μοριακής Βιολογίας VI
Περιεχόμενα αυτού του βιβλίου: Αντίστροφη transfection, Διαδικασία, Πλεονεκτήματα και μειονεκτήματα, ανάλυση ριβοσωματικών διαγονιδιακών διαχωριστικών, Ribosome προφίλ, Χρήσεις, Διαδικασία, Υλικά, RNase H-εξαρτώμενη PCR, Αρχή, Εφαρμογές, PCR Εκτεταμένη μεταγραφή, Sanger προσδιορισμός αλληλουχίας, Μέθοδος, Sanger Μικρο-ρευστή αλληλουχία Sanger, Δοκιμασία σύνδεσης και ενίσχυσης, Μέθοδος, Εφαρμογές, Αλληλο...
Molekuláris biológiai technikák II
1960 körül a molekuláris biológusok módszereket dolgoztak ki a sejtek molekuláris komponenseinek azonosítására, izolálására és manipulálására, ideértve a DNA, RNA és fehérjéket. A könyv tartalma: CRISPR génszerkesztés, CRISPR, Prime szerkesztés, Anti-CRISPR, transzfekció, gén knock-in, gén knockout, GeneTalk, Haplarithm, Haplarithmisis, Helicase-dependent amplification, Immunoprecipitation, izoelektromos fókuszálás, Isopeptag, Jumping library, Knockout moss, Kodecyte, Kodevirion, Ligáz láncreakció, Ligáció (molekuláris biológia), Mágneses asszisztens transfection, MassTag-PCR, Maxam-Gilbert szekvenálás, Módszerek protein-protein kölcsönhatások vizs...
