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The Gb3-enriched CD59/flotillin Plasma Membrane Domain Regulates Host Cell Invasion by Pseudomonas Aeruginosa
Abstract: The opportunistic pathogen Pseudomonas aeruginosa has gained precedence over the years due to its ability to develop resistance to existing antibiotics, thereby necessitating alternative strategies to understand and combat the bacterium. Our previous work identified the interaction between the bacterial lectin LecA and its host cell glycosphingolipid receptor globotriaosylceramide (Gb3) as a crucial step for the engulfment of P. aeruginosa via the lipid zipper mechanism. In this study, we define the LecA-associated host cell membrane domain by pull-down and mass spectrometry analysis. We unraveled a predilection of LecA for binding to saturated, long fatty acyl chain-containing Gb3...
Septin Barriers Protect Mammalian Host Cells Against Pseudomonas Aeruginosa Invasion
Abstract: Septin GTPases polymerize into higher-ordered structures as a part of the cytoskeleton and are involved in interactions of the host with a wide spectrum of pathogens. Many pathogens foster an ambiguous relationship with septins. They exploit septins for uptake, but septins also prevent their intracellular replication and target them for autophagy. We demonstrate that septins are involved in a defense mechanism against the pathogen Pseudomonas aeruginosa, which enters cells via a lipid zippering mechanism relying on interaction of the lectin LecA with the glycosphingolipid Gb3 on the host membrane. LecA-dependent invagination of the plasma membrane triggers septin recruitment to the site of bacterial attachment. We also find a septin-dependent reinforcement of cortical actin at attachment sites. Atomic force microscopy reveals formation of a septin-dependent rigid barrier below the membrane, preventing bacterial penetration. Our data suggest that septin barriers represent a cellular defense against bacteria inducing membrane curvature for invasion
Sahaja Yoga is Not
"Sahaja Yoga is not so simple as you think," Shri Mataji told us in 1998. "It is full of temptations." Over twelve pages, in a collection of short quotes, Shri Mataji clearly tells us what Sahaja Yoga is not. The magazine also includes several other articles created from her words. She speaks of collectivity, beauty, fear and incarnations. She speaks at a 1982 Shri Durga Puja, calling it "the Day of the Goddess" and she assures us that there is no problem because there is a special grace.
One Hundred and Eight Questions
At public programs, informal gatherings and media interviews, Shri Mataji often invited questions – from Sahaja Yogis, seekers, journalists. She satisfied our curiosity, our concerns. And calmed our confusions. Here are 108 of those questions, some naive, some misguided, but mostly insightful, rich and relevant. Each one is answered with love and patience. As one seeker prefaced his query, “We are not human beings having a spiritual experience, but we are spiritual beings having a human experience.” Shri Mataji agreed. “You have just become loving angels,” She said.
Meta Modern Era
"Meta Modern Era" by Shri Mataji Nirmala Devi is a loving, compelling and powerful book that introduces a tangible spiritual breakthrough for the 21st century - spontaneous Self Realization through Sahaja Yoga meditation - which opens a new dimension in human awareness. Written by Nobel Peace Prize nominee and one of the greatest voices on spirituality, Shri Mataji Nirmala Devi, the book offers stunningly deep insights on the crises of our modern times and the solutions to their root problems. (Published by Divine Cool Breeze Books.)
The Mystery of Sound
Saraswati Ramans interest and dedication to Sahaja Yoga and its meditation led her to explore a course in medicine, leading to an MD in alternative medicine from the Indian Board for Alternative Sciences, Kolkata, and started off on her journey in music too by learning, just to discover the treatments of various diseases through music and Sahaja Yoga meditation. A lady full of positive vibes and approach toward every aspect of life; ever smiling, her journey to explore the culture of our country and its tradition has taken this form of a beautiful compilation of this literature. We are proud to have her as one of the gems of Sahaja yogis that are blooming on this earth. Jai Shri Mataji. With lots of love. Pramila Rao, Krez Kreations, real estate, AdFilms and media During the course of her growth in Sahaja Yoga, she met her music teacher Dr. Arun Apte, who greatly influenced her in music, which was also instrumental in bringing a profound change in her health. She continues to practice singing out of love for music, and its impact on the energy centers. I am sure readers of this book will be greatly benefited. Prabha Narayanan
Nano
Master the Fundamentals of Nanotechnology to Prepare for Nano-Related Career Opportunities If you want to move into the fast-growing field of nanotechnology, you can't afford to miss Nano--The Essentials. This career-building resource offers a rigorous, technological introduction to the fundamentals of nanotechnology, providing everything you need to enter this burgeoning discipline and prepare for nano-related jobs. Packed with over 100 detailed illustrations and lots of practical work-related advice, the book covers the experimental tools of nanotechnology, the basics of nanomaterials, and key applications in fields such as nanosensors, nanobiology, nanomedicine, and nanomachines. This on-...
Molecular Regulation of Endocytosis
Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.
Severe Infections Caused by Pseudomonas Aeruginosa
Severe Infections Caused by Pseudomonas aeruginosa emphasizes controversies worldwide in the diagnosis, treatment, prevention and pathogenesis of pseudomonas aeruginosa infections. By including both chapters written by European authors and chapters written by North American experts, the reader is ensured of receiving a broad spectrum of opinions on controversial topics. Special attention is paid to such topics as the diagnosis of hospital-acquired pneumonia caused by p. aeruginosa, scheduled antibiotic therapy for patients with cystic fibrosis, empiric therapy for febrile neurotropenic patients, combination vs. single agent antibiotic therapy for severely ill patients, and alternatives to conventional antibiotic therapies. This excellent overview of our current understanding of pseudomonas aeruginosa pathogenesis will prove useful to clinicians and microbiologists around the globe.
