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Handbook of Mitochondrial Dysfunction
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
Polyglutamine Disorders
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s dise...
Ambient Intelligence – Software and Applications –,10th International Symposium on Ambient Intelligence
This book presents the latest research on Ambient Intelligence including software and applications. Ambient Intelligence (AmI) is a paradigm emerging from Artificial Intelligence, in which computers are used as proactive tools for assisting people with their day-to-day activities, making everyone’s lives more comfortable. Another main concern of AmI originates from the human–computer interaction domain and focuses on offering ways to interact with systems in a more natural way by means of user-friendly interfaces. This field is evolving rapidly, as can be seen in emerging natural language and gesture-based types of interaction. This symposium was jointly organized by the Universidade do Minho, Technical University of Valencia, Hiroshima University, and University of Salamanca. The latest installment was held in Ávila, Spain, from 26th to 28th June 2019. The authors wish to thank the sponsors: IEEE Systems Man and Cybernetics Society, Spain Section Chapter and the IEEE Spain Section (Technical Co-Sponsor), IBM, Indra, Viewnext, Global Exchange, AEPIA, APPIA and AIR Institute.
Intelligent Data Engineering and Automated Learning – IDEAL 2020
This two-volume set of LNCS 12489 and 12490 constitutes the thoroughly refereed conference proceedings of the 21th International Conference on Intelligent Data Engineering and Automated Learning, IDEAL 2020, held in Guimaraes, Portugal, in November 2020.* The 93 papers presented were carefully reviewed and selected from 134 submissions. These papers provided a timely sample of the latest advances in data engineering and machine learning, from methodologies, frameworks, and algorithms to applications. The core themes of IDEAL 2020 include big data challenges, machine learning, data mining, information retrieval and management, bio-/neuro-informatics, bio-inspiredmodels, agents and hybrid intelligent systems, real-world applications of intelligent techniques and AI. * The conference was held virtually due to the COVID-19 pandemic.
Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System
The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other ...
Retinal Vascular Disease
Vascular diseases of the retina are a major cause of blindness among all age groups. Edited and written by internationally well-known experts, this state-of-the-art comprehensive overview of basic and clinical science will enhance the understanding of retinal vascular disease and help in the evaluation of current and future treatment approaches for the clinician. The well-structured and highly illustrated text is divided into three easy-to-follow sections. This unique textbook-atlas also includes topics which are not currently found in other retinal disease textbooks, such as case reports and clinical follow-ups.
Interaction Between Neurons and Glia in Aging and Disease
A superb source of reference reviews as well as a concise overview of the functional cross-talk between neurons and glial cells, this book also focuses on microglia and inflammation in the aging brain and in neurological disorders. The scientific spectrum covered by this book is of key interest, and is recognized by the scientific community as a major competitive area with critical implications for human health.
Exponer o exponerse
Museos y centros de arte llevan varias décadas inmersos en un proceso de cambio, tratando de transitar desde una concepción más patrimonialista de la producción artística, a otra que busca atender a una diversidad de públicos y de actividades, orientada a la producción de conocimientos y experiencias y hacia un modelo socialmente transformador y más democrático de institucionalidad. En dicho proceso, la educación y la mediación han alcanzado una importancia creciente, como atestigua la creación de departamentos de educación y acción cultural (DEAC). Pero en un contexto de recesión económica y política, su evolución ha venido marcada por distintos obstáculos y contradiccion...
