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The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy
This chapter describes the steps from basic research to the definition of a putative public health recommendation in the clinical protocols and therapeutic guidelines for selenium (Se) supplementation for patients with Chagas disease. From 1998 to 2018, we conducted a translational research project to test the concept that chronic Chagas disease cardiopathy (CCC) severity could be associated with low levels of blood selenium (Se), and if oral Se supplementation could help to sustain the asymptomatic cardiac stage and reduce disease severity. Pre-clinical studies in mice and a clinical trial conducted in the early asymptomatic cardiac stage of CCC patients (B stage) were performed, identified...
Translational Research on Chagas Disease
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease endemic to Latin America, associated to significant morbimortality comprising a remarkable socioeconomic problem mainly for low-income tropical populations. The present chapter focuses translational research on Chagas disease, approaching drug combinations and repositioning, particularly exploiting the parasite oxidative stress by prospecting prooxidant compounds combined with antagonists of antioxidant systems, for developing low-cost and safe therapies for this infection. The pertinent literature on protozoal parasitic diseases is reviewed as well as on repurposing disulfiram aiming the combination with...
Chagas Disease
This book provides a comprehensive resource on various aspects of the parasite Trypanosoma cruzi and the neglected tropical disease Chagas disease (American trypanosomiasis), the disorder resulting from infection with the parasite. Topics include the biological description and taxonomy of the parasite, epidemiology and transmission routes, laboratory techniques in use when working with the parasite, as well as diagnostic measures and treatment of Chagas disease. Furthermore, a chapter with life stories of people in contact with the disease in endemic as well as non-endemic countries is included. The book is therefore a valuable source for individuals engaged in basic research as well as patient care and health management related to American trypanosomiasis.
Education Systems Around the World
This book, "Education Systems Around the World", is a collection of reviewed and relevant research chapters that offer a comprehensive overview of recent developments in the field of social sciences and humanities. The book comprises single chapters authored by various researchers and edited by an expert active in the field of social studies and humanities. All chapters are unique but are united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts by international authors on social studies and humanities, and open new possible research paths for further novel developments.
Teaching First-Year Communication Courses
In this book, eleven teacher-scholars of communication provide a robust study of the challenges and opportunities facing those who teach first-year communication courses. The first half of the volume offers paradigmatic analyses, including a survey of the ecology of the first-year course, a plea to integrate our first-year courses into our research agendas, a study of the gap between scholarship and pedagogy within rhetoric, a proposal for seven core competencies to unify the various first-year communication courses, and an argument for a critical communication paradigm. The second half details innovations in classroom practice, such as the teaching techniques of social justice pedagogues, team-based learning as a model for the public speaking course, response and feedback techniques in teaching public speaking at the University of Copenhagen, teaching online speech as a new course focused on the unique challenges of digital communication, and the role of oral interpretation and performance classes in the first-year curriculum. Finally, this volume concludes with the editor’s manifesto for teaching public speaking.
Information and Communication Technologies for Agriculture—Theme II: Data
This volume is the second (II) of four under the main themes of Digitizing Agriculture and Information and Communication Technologies (ICT). The four volumes cover rapidly developing processes including Sensors (I), Data (II), Decision (III), and Actions (IV). Volumes are related to ‘digital transformation” within agricultural production and provision systems, and in the context of Smart Farming Technology and Knowledge-based Agriculture. Content spans broadly from data mining and visualization to big data analytics and decision making, alongside with the sustainability aspects stemming from the digital transformation of farming. The four volumes comprise the outcome of the 12th EFITA Co...
Unforgetting
An LA Times Best Book of the Year • A New York Times Editors' Pick • A Newsweek 25 Best Fall Books • A The Millions Most Anticipated Book of the Year "Gripping and beautiful. With the artistry of a poet and the intensity of a revolutionary, Lovato untangles the tightly knit skein of love and terror that connects El Salvador and the United States." —Barbara Ehrenreich, author of Natural Causes and Nickel and Dimed An urgent, no-holds-barred tale of gang life, guerrilla warfare, intergenerational trauma, and interconnected violence between the United States and El Salvador, Roberto Lovato’s memoir excavates family history and reveals the intimate stories beneath headlines about gang ...
