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Translational Research on Chagas Disease
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease endemic to Latin America, associated to significant morbimortality comprising a remarkable socioeconomic problem mainly for low-income tropical populations. The present chapter focuses translational research on Chagas disease, approaching drug combinations and repositioning, particularly exploiting the parasite oxidative stress by prospecting prooxidant compounds combined with antagonists of antioxidant systems, for developing low-cost and safe therapies for this infection. The pertinent literature on protozoal parasitic diseases is reviewed as well as on repurposing disulfiram aiming the combination with...
Fermentation Processes
Fermentation is a theme widely useful for food, feed and biofuel production. Indeed each of these areas, food industry, animal nutrition and energy production, has considerable presence in the global market. Fermentation process also has relevant applications on medical and pharmaceutical areas, such as antibiotics production. The present book, Fermentation Processes, reflects that wide value of fermentation in related areas. It holds a total of 14 chapters over diverse areas of fermentation research.
Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
1st International Congress and Exhibition on Sustainability in Music, Art, Textile and Fashion (ICESMATF 2023) January, 26-27 Madrid, Spain ABSTRACT BOOK
ICSSIET CONGRESS 1st International Congress and Exhibition on Sustainability in Music, Art, Textile and Fashion (ICESMATF 2023) January, 26-27 Madrid, Spain ABSTRACT BOOK Editor Assoc. Prof. Shajara Ul DURAR ISBN: 978-625-8284-27-0 Publishing Date: 28.01.2023 All rights of this book belong to Global Academy Publishing House. No part of this publication may be reproduced, stored, retrieved system, ortransmitted, in any form or by any means, without the written permission of the Global Academy Publishing House. Norbe otherwise circulated in any form of binding or cover. ©Copyright January, 2023 Certificate No: 64419 Publisher: Global Academy Publishing House globalyayinlari@gmail.com https://www.globalacademy.com.tr/ The individual essays remain the intellectual properties of the contributors. All papers published in this abstract book have been peer reviewed. https://www.icssietcongress.com/icesmatf-2023
Fluorescent Markers
This book chapter will comment on fluorescent reporter proteins and nanocrystals,Äô applicability as fluorescent markers. Fluorescent reporter proteins in the Drosophila model system offer a degree of specificity that allows monitoring cellular and biochemical phenomena in vivo, such as autophagy, mitophagy, and changes in the redox state of cells. Titanium dioxide (TiO2) nanocrystals (NCs) have several biological applications and emit in the ultraviolet, with doping of europium ions can be visualized in the red luminescence. Therefore, it is possible to monitor nanocrystals in biological systems using different emission channels. CdSe/CdS magic-sized quantum dots (MSQDs) show high luminescence stability in biological systems and can be bioconjugated with biological molecules. Therefore, this chapter will show exciting results of the group using fluorescent proteins and nanocrystals in biological systems.
Participatory Biodiversity Conservation
It has long been claimed that addressing biodiversity loss and other environmental problems demands a better understanding of the social dimensions of conservation; nevertheless, the active participation of indigenous peoples and local communities (IPLCs) in conservation initiatives is still a challenging and somehow controversial issue. In this context, this book hopes to give voice to other perspectives related to biodiversity conservation beyond the “fortress conservation” model and emphasize one of the pillars of democracy – popular participation. It covers a wide range of environments and issues of special significance to the topic, such as the expansion of culturally constructed ...
Tracheostomy
Despite often taken as a simple procedure, techniques on tracheostomy have evolved considerably on the last few years. Consequently, new technical variations and indications for different purposes are being developed and proposed. The current book is proposed to serve as a comprehensive guide exclusively devoted to tracheostomy, discussing its most important details, variations and indications. Here the reader will find a broad discussion ranging from the most basic pre-clinical aspects to post-surgical procedures and complications. Great emphasis is placed on key topics such as the oncologic patient, variations of the technique, and tracheostomy in the intensive care unit, among others. Additionally, some issues that are not commonly discussed in regular textbooks, like tracheostomy in child and in great obese, are also included. With a wealth of photos, illustrations and tables, Tracheostomy – A Surgical Guide provides the material necessary to support a safe and effective surgical intervention in different populations and surgical contexts, with the hope that it will result in improved care for patients who underwent tracheostomy.
Recent Advances in Complex Functional Materials
In this book we explore new approaches to understanding the physical and chemical properties of emergent complex functional materials, revealing a close relationship between their structures and properties at the molecular level. The primary focus of this book is on the ability to synthesize materials with a controlled chemical composition, a crystallographic structure, and a well-defined morphology. Special attention is also given to the interplay of theory, simulation and experimental results, in order to interconnect theoretical knowledge and experimental approaches, which can reveal new scientific and technological directions in several fields, expanding the versatility to yield a variet...
