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Targeting the Broadly Pathogenic Kynurenine Pathway
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in...
Genetics of Bipolar Disorder
The high hereditary factor of Bipolar Disorder has been proven by many twin-, adoption- and family-studies already decades ago. A detailed and exciting description is given within this book. Furthermore basic principles of genetics and gene-environment-interactions are described to picture the whole painting of Genetics of Bipolar Disorder.
Russian Law Journal
The “Russian Law Journal” (RLJ) magazine is one of the first English-language legal academic editions regularly published in Russia. It is an All-Russian interuniversity platform designed to promote Russian legal researches abroad. The magazine is meant for both Russian and foreign readers including major world legal libraries, academics and practicing lawyers. International editorial board and editorial team are represented by professors from leading world centers of legal education and legal science, like Harvard, Yale, Cambridge and La Sorbonne, as well as by scientists from Russian law schools (Moscow State University, Kutafin Moscow State Law University, Saint-Petersburg State University, Higher School of Economics).
Effects of Nutrition, Exercise and the Gut-Brain Axis on Psychiatric Disorders
This special topic issue of 'Neuropsychobiology' contains contributions discussing the subject in-depth. 'Neuropsychobiology' is a well-respected, international peer-reviewed journal in psychiatry. Special topic issues are included in the subscription.
Sicherheiten am Bau nach BGB und VOB/B
Der rechtlichen Sicherheit kommt im Bauwesen eine große Bedeutung zu, weil sie die Insolvenz des Vertragspartners absichert. Trotzdem wird das Risiko im Umgang mit solchen Sicherheiten oft verkannt. Bereits bei Vertragsabschluss treten Fragen im Zusammenhang mit der Gestaltung der Sicherungsabrede auf, im weiteren Bauverlauf kann es zu Problemen bei der Übergabe oder dem Austausch von Sicherheiten kommen. Schließlich gilt es noch, Fragen in Zusammenhang mit der Rückgabe oder Inanspruchnahme von Sicherheiten zu klären. Dieses Beuth Pocket gibt allen am Bau Beteiligten, angefangen beim Bauherren über Planer und Ingenieure bis hin zum Handwerker, praktische Hinweise, wie solche Risiken schon im Vorfeld vermieden und bereits aufgetretene Fragestellungen bewältigt werden können.
Fat: the Secret Organ
The International Bestseller, as featured in The Times Fat is a vital yet hugely under-rated organ. Fat has become a dirty word, but we know so little about how it really works. In Fat, expert doctors and obesity researchers Dr Mariëtte Boon and Professor Liesbeth van Rossum present the ground-breaking research which explodes many of the myths and prejudices surrounding body fat and will make us completely rethink our relationship with it. Making use of the cutting-edge research in this specialist field, this fascinating and entertaining book will explain how fat generates important hormones, communicates with our brains and is, indeed, essential for staying alive. Informative yet accessible, Fat: The Secret Organ is important reading, not only for people who have struggled with their weight, but for everybody who is serious about their health.
Rechtsfragen der Technischen Ausrüstung
Das Leistungsbild Technische Ausrüstung weist gegenüber den weiteren Sparten des Bauwesens eine Vielzahl von Besonderheiten auf, insbesondere bei der Honorierung sowie den Grundleistungen der einzelnen Leistungsphasen. Der Schwerpunkt des Buches liegt in der Erörterung dieser Besonderheiten und gibt Ingenieuren sowie Bauherrenvertretern praxisrelevante Hinweise, wie Risiken vermieden und relevante Fragestellungen bewältigt werden können. Aus dem Inhalt: // Grundsätze des Ingenieurvertrags Technische Ausrüstung // Anlagengruppen // Allgemeine und besondere Grundlagen der Honorierung // Leistungsbild Technische Ausrüstung // Grundleistungen der einzelnen Leistungsphasen // Besondere Leistungen.
