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2 March 1810 . . . Today, I fell in love. At the age of ten, Miranda Cheever showed no signs of Great Beauty. And even at ten, Miranda learned to accept the expectations society held for her—until the afternoon when Nigel Bevelstoke, the handsome and dashing Viscount Turner, solemnly kissed her hand and promised her that one day she would grow into herself, that one day she would be as beautiful as she already was smart. And even at ten, Miranda knew she would love him forever. But the years that followed were as cruel to Turner as they were kind to Miranda. She is as intriguing as the viscount boldly predicted on that memorable day—while he is a lonely, bitter man, crushed by a devastating loss. But Miranda has never forgotten the truth she set down on paper all those years earlier—and she will not allow the love that is her destiny to slip lightly through her fingers . . .
Neste caderno de resumos expandidos estão contidos os resultados prévios de 22 das investigações em desenvolvimento, distribuídas nas mais variadas temáticas, dentro das duas linhas: práticas de pesquisa em ensino de humanidades e formação de professores em ensino de humanidades. Os textos aqui organizados referem-se ao IV SEHUM - Seminário de Pesquisa em Ensino de Humanidades, ocorrido em setembro de 2019.
Os capítulos presentes nesta obra contemplam, na sua constituição e percurso, de algum modo o exercício da Psicologia para os estudos e análises dos processos intrapessoais e das relações interpessoais, possibilitando a compreensão do comportamento humano individual e de grupo, no âmbito das instituições de várias naturezas, onde quer que se deem estas relações. Por conseguinte, os assuntos abarcados nesta obra destacam-se por demonstrar a aplicação do conhecimento teórico e técnico da Psicologia, com o objetivo de identificar e intervir nos fatores determinantes das ações e dos sujeitos, em sua história pessoal, familiar e social, vinculando-as também a condições políticas, históricas e culturais. Diante disso, apreende-se que o Psicólogo, dentro de suas especificidades profissionais, atua no âmbito da educação, saúde, lazer, trabalho, segurança, justiça, comunidades e comunicação com o objetivo de promover, em seu trabalho, o respeito à dignidade e integridade do ser humano.
* Instant NEW YORK TIMES and USA TODAY bestseller * * GOODREADS CHOICE AWARD WINNER for BEST DEBUT and BEST ROMANCE of 2019 * * BEST BOOK OF THE YEAR* for VOGUE, NPR, VANITY FAIR, and more! * What happens when America's First Son falls in love with the Prince of Wales? When his mother became President, Alex Claremont-Diaz was promptly cast as the American equivalent of a young royal. Handsome, charismatic, genius—his image is pure millennial-marketing gold for the White House. There's only one problem: Alex has a beef with the actual prince, Henry, across the pond. And when the tabloids get hold of a photo involving an Alex-Henry altercation, U.S./British relations take a turn for the wors...
Explores the transformation of punishment in ninteneeth-century Brazil and its intersection with changes in labor relations in the Atlantic World.
The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic dr...
This book provides an in-depth overview on the manifold functions of fungal extracellular vesicles (EV) which span from cell-to-cell communication, pathogenicity and stimulation of host’s immunity to export of hundreds of biomolecules. The book summarizes the present knowledge on the impact of extracellular vesicles on fungal biology. Extracellular vesicles participate in fundamental biological processes in all living cells but only during the last 15 years the production and functions of EVs were identified and studied in fungal species too. Up to date more than 50 independent studies have shown that extracellular vesicles are produced by at least 20 fungal species. The book addresses researchers and advanced students in Microbiology, Mycology and Biotechnology.
This book covers basic aspects of different nanoparticles, including type of materials, lipid, polymeric and inorganic structures, synthesis strategies, as well as the main physicochemical characterization techniques. Moreover, this book addresses applications for both treatment and diagnosis of diseases, highlighting in vitro and in vivo findings and clinical evaluation. The chapters highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy and functionalization of nanoparticles with a variety of moieties, including monoclonal antibodies for selective delivery, are discussed and illustrated with examples. Finally, the application of nanoparticles for drug delivery to cancer is reviewed considering toxicology and regulatory aspects.
This book is a collection of articles written by prominent scientists who gathered in the city of Recife, Brazil, 23-27 October 2010, celebrating the 10th International Symposium on Yersinia. The event is held every four years in a different country and for the Yersinia 2010, an interesting and updated program covering advances in research in Yersiniae was organized. The major advances achieved over the past four years since the last symposium held in Lexington, USA in 2006 were divided into eight chapters: Epidemiology, Clinical, Diagnostic and Therapeutic aspects; Ecology and Modeling; Genomic/Transcriptomics and Large Scale Population; Immune Response and Vaccine; Pathogenesis and Pathogenicity Factors; Cellular Yersiniology; Bacterial Structure and Metabolism: Roles in Pathogenesis and Bacterial Life Style. The purpose of the book is to extend cutting edge knowledge on Yersinia discussed during the 10th International Symposium.